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Comprehensive Physiology publishes articles in the interdisciplinary field of inter-organ communication in health and disease. Example topics include inter-organ cellular communication, signaling pathways, organ crosstalk, systems biology, inter-organ pathology and pathogenesis, and the role of hormones and neurotransmitters. The journal provides essential insights for developing interventions and treatments. It features research articles, reviews, and editorials.
A journal of the American Physiological Society, serving the dynamic and global physiology community.
Journal Metrics
- 5.2Journal Impact Factor
- 75%Acceptance rate
- 19 days Submission to first decision
Articles
Microbiota in Gut‐Heart Axis: Metabolites and Mechanisms in Cardiovascular Disease
-  21 June 2025
Lysosomal Acidification: A New Perspective on the Pathogenesis and Treatment of Pulmonary Fibrosis
-  18 June 2025
Graphical Abstract

Lysosomal acidification dysfunction contributes to pulmonary fibrosis by affecting epithelial cells, endothelial cells, macrophages, and fibroblasts. During fibrosis progression, pro-inflammatory and pro-fibrotic factors such as IL-6, TNF-α, and TGF-β can exert systemic effects on organs including the heart, liver, and kidneys through the blood-air barrier.
Kidney‐Heart‐Lung Interorgan Communication Networks in Health and Disease
-  10 June 2025
Mechanistic Insights Into Long Covid: Viral Persistence, Immune Dysregulation, and Multi‐Organ Dysfunction
-  6 June 2025
Maternal Nutritional Environment and the Development of the Melanocortin System
-  6 June 2025
Graphical Abstract

Maternal metabolic impairments are related to an increased risk of obesity in the offspring throughout life, and changes in the development of the melanocortin system may be one of the mechanisms that promote increased food intake in the long term, leading to a positive energy balance and increased fat deposition.
The following is a list of the most cited articles based on citations published in the last three years, according to CrossRef.
Regulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response
-  603-621
-  1 April 2016
Energy Metabolism in the Liver
-  177-197
-  1 January 2014
Lack of Exercise Is a Major Cause of Chronic Diseases
-  1143-1211
-  1 April 2012
Bile Acid Metabolism and Signaling
-  1191-1212
-  1 July 2013
Triglyceride Metabolism in the Liver
-  1-22
-  1 January 2018
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Recent issues
- Volume 15, Issue 3June 2025
- Volume 15, Issue 2April 2025
- Volume 15, Issue 1February 2025