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Comprehensive Physiology publishes articles in the interdisciplinary field of inter-organ communication in health and disease. Example topics include inter-organ cellular communication, signaling pathways, organ crosstalk, systems biology, inter-organ pathology and pathogenesis, and the role of hormones and neurotransmitters. The journal provides essential insights for developing interventions and treatments. It features research articles, reviews, and editorials.
A journal of the American Physiological Society, serving the dynamic and global physiology community.
Journal Metrics
- 5.2Journal Impact Factor
- 75%Acceptance rate
- 19 days Submission to first decision
Check out the new Review written by Paola C. Rosas and R. John Solaro, “p21-Activated Kinase 1 (Pak1) as an Element in Functional and Dysfunctional Interplay Among the Myocardium, Adipose Tissue, and Pancreatic Beta Cells” now available!
Check out the new Review titled “Redefining Macrophage Heterogeneity in Atherosclerosis: A Focus on Possible Therapeutic Implications” written by Babunageswararao Kanuri, Krishna P. Maremanda, Dipanjan Chattopadhyay, M. Faadiel Essop, Man Kit Sam Lee, Andrew J. Murphy, and Prabhakara R. Nagareddy, now available!
New Article Available titled “Synergistic Effects of Riluzole and Sodium Butyrate on Barrier Function and Disease Progression of Amyotrophic Lateral Sclerosis Through the Gut-Neuron Axis” written by: Yongguo Zhang, KaReisha Robinson, Yinglin Xia, and Jun Sun. Read here now!
Articles
Microbiota in Gut‐Heart Axis: Metabolites and Mechanisms in Cardiovascular Disease
- 21 June 2025
Graphical Abstract
Influence of Dietary and Lifestyle Factors on Gut Microbiota and Cardiovascular Health.
Lysosomal Acidification: A New Perspective on the Pathogenesis and Treatment of Pulmonary Fibrosis
- 18 June 2025
Graphical Abstract
Lysosomal acidification dysfunction contributes to pulmonary fibrosis by affecting epithelial cells, endothelial cells, macrophages, and fibroblasts. During fibrosis progression, pro-inflammatory and pro-fibrotic factors such as IL-6, TNF-α, and TGF-β can exert systemic effects on organs including the heart, liver, and kidneys through the blood-air barrier.
Mechanistic Insights Into Long Covid: Viral Persistence, Immune Dysregulation, and Multi‐Organ Dysfunction
- 6 June 2025
Maternal Nutritional Environment and the Development of the Melanocortin System
- 6 June 2025
Graphical Abstract
Maternal metabolic impairments are related to an increased risk of obesity in the offspring throughout life, and changes in the development of the melanocortin system may be one of the mechanisms that promote increased food intake in the long term, leading to a positive energy balance and increased fat deposition.
The following is a list of the most cited articles based on citations published in the last three years, according to CrossRef.
Regulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response
- 603-621
- 1 April 2016
Energy Metabolism in the Liver
- 177-197
- 1 January 2014
Lack of Exercise Is a Major Cause of Chronic Diseases
- 1143-1211
- 1 April 2012
Bile Acid Metabolism and Signaling
- 1191-1212
- 1 July 2013
Latest news
Recent issues
Volume 15, Issue 3June 2025
Volume 15, Issue 2April 2025
Volume 15, Issue 1February 2025
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Key Features
- A dynamic online quarterly review journal with the breadth and depth of a reference work. A world-class editorial team comprising leading names in the field
- Fully citable content, indexed in major indexing and abstracting services, including MEDLINE/PubMed
- Includes more than 30,000 pages of classic content digitized from prestigious Handbook of Physiology series
- As an online reference work, articles can be updated when new information is available
- Find the information you need by searching or browsing by keywords, topic, or issue