Comprehensive Physiology publishes articles in the interdisciplinary field of inter-organ communication in health and disease. Example topics include inter-organ cellular communication, signaling pathways, organ crosstalk, systems biology, inter-organ pathology and pathogenesis, and the role of hormones and neurotransmitters. The journal provides essential insights for developing interventions and treatments. It features research articles, reviews, and editorials.

A journal of the American Physiological Society, serving the dynamic and global physiology community.

Journal Metrics

  • 5.2Journal Impact Factor
  • 75%Acceptance rate
  • 19 days Submission to first decision
view all metrics
Skip slideshow

Articles

REVIEW
Open access

Microbiota in Gut‐Heart Axis: Metabolites and Mechanisms in Cardiovascular Disease

  •  21 June 2025

Graphical Abstract

Microbiota in Gut-Heart Axis: Metabolites and Mechanisms in Cardiovascular Disease Issue 3, 2025

Influence of Dietary and Lifestyle Factors on Gut Microbiota and Cardiovascular Health.

REVIEW

Lysosomal Acidification: A New Perspective on the Pathogenesis and Treatment of Pulmonary Fibrosis

  •  18 June 2025

Graphical Abstract

Lysosomal Acidification: A New Perspective on the Pathogenesis and Treatment of Pulmonary Fibrosis Issue 3, 2025

Lysosomal acidification dysfunction contributes to pulmonary fibrosis by affecting epithelial cells, endothelial cells, macrophages, and fibroblasts. During fibrosis progression, pro-inflammatory and pro-fibrotic factors such as IL-6, TNF-α, and TGF-β can exert systemic effects on organs including the heart, liver, and kidneys through the blood-air barrier.

REVIEW
Open access

Maternal Nutritional Environment and the Development of the Melanocortin System

  •  6 June 2025

Graphical Abstract

Maternal Nutritional Environment and the Development of the Melanocortin System Issue 3, 2025

Maternal metabolic impairments are related to an increased risk of obesity in the offspring throughout life, and changes in the development of the melanocortin system may be one of the mechanisms that promote increased food intake in the long term, leading to a positive energy balance and increased fat deposition.

More articles

Latest news

Recent issues