Comprehensive Physiology publishes articles in the interdisciplinary field of inter-organ communication in health and disease. Example topics include inter-organ cellular communication, signaling pathways, organ crosstalk, systems biology, inter-organ pathology and pathogenesis, and the role of hormones and neurotransmitters. The journal provides essential insights for developing interventions and treatments. It features research articles, reviews, and editorials.

A journal of the American Physiological Society, serving the dynamic and global physiology community.

Journal Metrics

  • 4.2Journal Impact Factor
  • 75%Acceptance rate
  • 19 days Submission to first decision
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Articles

REVIEW
Open access

Maternal Nutritional Environment and the Development of the Melanocortin System

  •  6 June 2025

Graphical Abstract

Maternal Nutritional Environment and the Development of the Melanocortin System Issue 3, 2025

Maternal metabolic impairments are related to an increased risk of obesity in the offspring throughout life, and changes in the development of the melanocortin system may be one of the mechanisms that promote increased food intake in the long term, leading to a positive energy balance and increased fat deposition.

REVIEW

Adipose Tissue‐Derived Adipokines in Vascular Physiology and Pathophysiology: Insights and Implications

  •  1 June 2025

Graphical Abstract

Adipose Tissue-Derived Adipokines in Vascular Physiology and Pathophysiology: Insights and Implications Issue 3, 2025

Abnormal alterations in the amount and quality of adipose tissue result in dysregulated adipokine production—molecules secreted by adipocytes—which in turn contribute to vascular changes such as dysfunction, inflammation, and remodeling.

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