Ebert Prize - Free Virtual Issue

The Ebert Prize is presented annually by the American Pharmacists Association (APhA) Academy of Pharmaceutical Research and Science to the authors of an article published in the Journal of Pharmaceutical Sciences (JPharmSci™), which describes particularly new, original, and novel findings that have a high probability of significantly impacting the pharmaceutical sciences. The Ebert Prize was established in 1873 and it is the oldest pharmacy award in existence in the United States. The award consists of a silver medallion bearing the likeness of Albert Ethelbert Ebert who was a former APhA President. These articles are freely available and we hope you enjoy reading them.

1961    

Enteric coatings. IV. In vivo testing of granules and tablets coated with styrene-maleic acid copolymer

WAGNER JG, VELDKAMP W, LONG S. 

 

 

1962

Biological disposition of apomorphine. II. Urinary excretion and organ distribution of apomorphine

KAUL PN, BROCHMANN-HANSSEN E, WAY EL

 

Biological disposition of apomorphine. III. Kinetics of metabolism of apomorphine and role of the liver in its biotransformation

KAUL PN, BROCHMANN-HANSSEN E, WAY EL

 

Auto-oxidation of apomorphine

KAUL PN, BROCHMANN-HANSSEN E

 

Biological disposition of apomorphine. IV. Isolation and characterization of "bound" apomorphine

KAUL PN, BROCHMANN-HANSSEN E, WAY EL

 

 

1963

Selection, evaluation, and control of the assay of the pharmaceutical product. V. Importance of assay validity, a case in point

GARRETT ER  

 

Prediction of stability of drugs and pharmaceutical preparations

GARRETT ER

 

Selection, evaluation, and control of the assay of the pharmaceutical product. I. Reproducibilities of assay and drug recovery from dosage forms

GARRETT ER

 

Characterization and mode of degradation of the neurophysiologically important transaminase inhibitors, the alpha-aminooxyalkanoic acids

GARRETT ER

 

Prediction of stability in pharmaceutical preparations. X. Alkaline hydrolysis of hydrocortisone hemisuccinate

GARRETT ER

 

Facile acid hydrolysis of p-chlorobenzaldozime and its oral inefficacy

GARRETT ER

 

Solvolysis of symmetrical and mixed aspirin anhydrides in 17 per cent dioxane-25 per cent water

GARRETT ER

 

Prediction of stability in pharmaceutical preparations. VIII. Oil-in-water emulsion stability and the analytical ultracentrifuge

GARRETT ER

 

 

1964

NONCLASSICAL ANTIMETABOLITES. XIV. SOME FACTORS IN DESIGN OF IRREVERSIBLE INHIBITORS EFFECTIVE AT LOW CONCENTRATION

BAKER BR, PATEL RP, ALMAULA P

 

NONCLASSICAL ANTIMETABOLITES. XIII. SIMULATION OF THE 5'PHOSPHORIBOSYL MOIETY OF 5'-ADENYLIC ACID AT THE ENZYME LEVEL BY OMEGA-CARBOXYALKYL AND ARALKYL GROUPS ATTACHED TO ADENINE

BAKER BR, SACHDEV HS

 

NONCLASSICAL ANTIMETABOLITES. XII. BRIDGE PRINCIPLE OF SPECIFICITY WITH EXO-ALKYLATING IRREVERSIBLE INHIBITORS. V. DIFFERENCES IN SPECIFICITY OF ENZYMIC NUCLEOPHILIC SITES AS DETECTED BY THE CARBOPHENOXY GROUP

BAKER BR, PATEL RP 

 

NONCLASSICAL ANTIMETABOLITES. XVI. THE BRIDGE PRINCIPLE OF SPECIFICITY WITH ACTIVE SITE-DIRECTED IRREVERSIBLE INHIBITORS. VII. DETECTION OF DIFFERENCES IN SPECIFICITY OF ENZYMIC NUCLEOPHILIC SITES BY THE MALEAMYL GROUP

BAKER BR, ALUMAULA PI 

 

ANALOGS OF TETRAHYDROFOLIC ACID. VII. SYNTHESIS OF N-(1-(2-AMINO- 4-HYDROXY-6-METHYL-5-PYRIMIDYL)-3-PROPYL)-P-AMINOBENZOYL-L-GLUTAMIC ACID, AN INHIBITOR OF FOLIC REDUCTASE

BAKER BR, MORREAL CE

 

 

1965

ENZYME INHIBITORS. 3. SYNTHESES OF CIS-(6-SUBSTITUTED-9-PURINYL) CYCLOALKYLCARBINOLS AS ADENOSINE DEAMINASE INHIBITORS

SCHAEFFER HJ, GODSE DD, LIU G 

 

ENZYME INHIBITORS. II. SYNTHESIS OF TRANS-3-(6-SUBSTITUTED-9-PURINYL) CYCLOHEXANOLS AS ADENOSINE DEAMINASE INHIBITORS

SCHAEFFER HJ, KAISTHA KK, CHAKROBORTI SK

 

ENZYME INHIBITORS. I. INHIBITION OF ADENOSINE DEAMINASE BY ISOSTERIC NUCLEOSIDES

SCHAEFFER HJ, MARATHE S, ALKS V

 

SYNTHESIS OF SOME TRICYCLIC ANALOGS OF TETRACYCLINE

SCHAEFFER HJ, CHHEDA GB 

 

CHEMICAL REACTIVITY OF MODELS RELATED TO A PROPOSED CO2-BIOTIN ENZYME COMPLEX. II

SCHAEFFER HJ, BHARGAVA PS

 

INVESTIGATION OF THE STEREOCHEMISTRY OF CYCLOHEXIMIDE

SCHAEFFER HJ, JAIN VK 

 

 

1966    

Biophysical study of the mode of action of the tetracycline antibiotics. Inhibition of metalloflavoenzyme NADH cytochrome oxidoreductase

Colaizzi JL, Knevel AM, Martin AN  

 

 

1967    

Alkaloids of Acronychia Baueri Schott I. Isolation of the alkaloids and a study of the antitumor and other biological properties of acronycine

Svoboda GH, Poore GA, Simpson PJ, Boder GB

 

 

1968    

Release rates of solid drug mixtures dispersed in inert matrices. I. Noninteracting drug mixtures

Singh P, Desai SJ, Simonelli AP, Higuchi WI

 

 

1969      

Comparative pharmacokinetics of coumarin anticoagulants. IV. Application of a three-compartmental model to the analysis of the dose-dependent kinetics of bishydroxycoumarin elimination

Nagashima R, Levy G, O'Reilly RA  

 

 

1970      

Interfacial barriers in interphase transport: retardation of the transport of diethylphthalate across the hexadecane-water interface by an adsorbed gelatin film

Ghanem AH, Higuchi WI, Simonelli AP 

 

 

1971      

Mechanisms of reactions of ring-substituted bis(1-aziridinyl)phosphinyl urethan antineoplastic agents

Navada CK, Chmielewicz ZF, Bardos TJ 

 

 

1972      

Methotrexate pharmacokinetics

Bischoff KB, Dedrick RL, Zaharko DS, Longstreth JA

 

 

1973      

Correlation and prediction of mass transport across membranes. I. Influence of alkyl chain length on flux-determining properties of barrier and diffusant

Flynn GL, Yalkowsky SH

 

 

1974      

Evaluation of interactions between polymers and low molecular weight compounds by GLC II: Thermodynamics and elucidation

Varsano JL, Gilbert SG

 

 

1975                

Solubility of nonelectrolytes in polar solvents II: solubility of aliphatic alcohols in water

Amidon GL, Yalkowsky SH, Leung S 

 

 

1976      

Solid-state decomposition of para-substituted salicylic acids

Pothisiri P, Carstensen JT

 

 

1977      

Vapor pressure of nitroglycerin in sublingual molded tablets: implications for stability

Pikal MJ, Lukes AL, Ellis LF

 

 

1978      

Physical processes of tableting

Hiestand EN, Wells JE, Peot CB, Ochs JF 

 

 

1979      

Pharmacokinetic model for salicyclate in cerebrospinal fluid, blood, organs, and tissues

Chen CN, Coleman DL, Andrade JD, Temple AR 

 

 

1980      

Physical model evaluation of topical prodrug delivery-simultaneous transport and bioconversion of vidarabine-5'-valerate I: Physical model development

Yu CD, Fox JL, Ho NF, Higuchi WI

 

 

1981

Not awarded

 

 

1982      

Viscoelastic stress/strain behavior of pharmaceutical tablets: analysis during unloading and postcompression periods

Rippie EG, Danielson DW 

 

 

1983      

Theoretical and experimental studies of transport of micelle-solubilized solutes

Amidon GE, Higuchi WI, Ho NF 

 

1984      

Moisture sorption kinetics for water-soluble substances. I: Theoretical considerations of heat transport control

Van Campen L, Amidon GL, Zografi G 

 

 

1985      

Pharmacokinetic study on the mechanism of tissue distribution of doxorubicin: interorgan and interspecies variation of tissue-to-plasma partition coefficients in rats, rabbits, and guinea pigs.
Terasaki T, Iga T, Sugiyama Y, Hanano M.

 

 

1986      

Inhibition of 5 beta-dihydrocortisone reduction in rat liver cytosol: a rapid spectrophotometric screen for nonsteroidal anti-inflammatory drug potency

Penning TM 

 

 

1987      

Mixing-tank model for predicting dissolution rate control or oral absorption

Dressman JB, Fleisher D 

 

 

1988      

Controlled-release drug delivery of diphosphonates to inhibit bioprosthetic heart valve calcification: release rate modulation with silicone matrices via drug solubility and membrane coating

Golomb G, Dixon M, Smith MS, Schoen FJ, Levy RJ 

 

 

1989      

Mechanisms of corneal drug penetration. III: Modeling of molecular transport

Grass GM, Cooper ER, Robinson JR 

 

 

1990    

Transdermal iontophoretic drug delivery: mechanistic analysis and application to polypeptide delivery

Srinivasan V, Higuchi WI, Sims SM, Ghanem AH, Behl CR 

 

 

1991      

A physiologically relevant pharmacokinetic model of xenobiotic percutaneous absorption utilizing the isolated perfused porcine skin flap

Williams PL, Carver MP, Riviere JE 

 

 

1992    

Role of hydrogen bonding in general anesthesia

Abraham MH, Lieb WR, Franks NP 

 

 

1993      

A time hierarchy-based model for kinetics of drug disposition and its use in quantitative structure-activity relationships

Baláz S, Wiese M, Seydel JK

 

 

1994      

Prediction of drug distribution in distribution dialysis and in vivo from binding to tissues and blood

Clausen J, Bickel MH 

 

 

1995      

A linear theory of transdermal transport phenomena

Edwards DA, Langer R 

 

 

1996      

A mechanistic study of ultrasonically-enhanced transdermal drug delivery

Mitragotri S, Edwards DA, Blankschtein D, Langer R

 

 

1997      

Correlation of drug absorption with molecular surface properties

Palm K, Luthman K, Ungell AL, Strandlund G, Artursson P 

 

 

1998      

Solid-state stability of human insulin. II. Effect of water on reactive intermediate partitioning in lyophiles from pH 2-5 solutions: stabilization against covalent dimer formation

Strickley RG, Anderson BD 

 

 

1999      

A theoretical model of erosion and macromolecular drug release from biodegrading microspheres

Batycky RP, Hanes J, Langer R, Edwards DA 

 

 

2000      

Powder densification. 1. Particle-particle basis for incorporation of viscoelastic material properties

Lum SK, Duncan-Hewitt WC 

 

 

2001      

The relationship between “BET” and “free volume”‐derived parameters for water vapor absorption into amorphous solids.

Zhang J, Zografi G 

 

 

2002      

“Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors”

Zhao YH, Le J, Abraham MH, Hersey A, Eddershaw PJ, Luscombe CN, Boutina D, Beck G, Sherborne B, Cooper I, Platts JA 

 

 

2003    

Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution

Poulin P, Theil FP

 

 

2004      

“Irreversible aggregation of recombinant bovine granulocyte-colony stimulating factor (bG-CSF) and implications for predicting protein shelf life”

Roberts CJ, Darrington RT, Whitley MB 

 

 

2005      

Surfactant-Facilitated Crystallization of Dihydrate Carbamazepine During Dissolution of Anhydrous Polymorph

Rodríguez-Hornedo N, Murphy D 

 

 

2006      

Dehydration Kinetics of Piroxicam Monohydrate and Relationship to Lattice Energy and Structure

Sheth AR, Zhou D, Muller FX, Grant DJ 

 

 

2007      

Effects of pH, Temperature, and Sucrose on Benzyl Alcohol-Induced Aggregation of Recombinant Human Granulocyte Colony Stimulating Factor

Thirumangalathu R, Krishnan S, Brems DN, Randolph TW, Carpenter JF 

 

 

2008      

In Vivo Drug Metabolism Model for Human Cytochrome P450 Enzymes Using Chimeric Mice with Humanized Liver

Katoh M, Sawada T, Soeno Y, Nakajima M, Tateno C, Yoshizato K, Yokoi T 

 

 

2009      

Oral Delivery of Antisense Oligonucleotides in Man

Tillman LG, Geary RS, Hardee GE 

 

 

2010      

Methodology for Development of a Physiological Model Incorporating CYP3A and P-Glycoprotein for the Prediction of Intestinal Drug Absorption

Badhan R, Penny J, Galetin A, Houston JB 

 

 

2011      

N-(3,4-Dimethoxyphenethyl)-4-(6,7-Dimethoxy-3,4-Dihydroisoquinolin-2[1H]-yl)-6,7-Dimethoxyquinazolin-2-Amine (CP-100,356) as a ‘Chemical Knock-out Equivalent’ to Assess the Impact of Efflux Transporters on Oral Drug Absorption in the Rat

Kalgutkar AS, Frederick KS, Chupka J, Feng B, Kempshall S, Mireles RJ, Fenner KS, Troutman MD

 

 

2012      

A Classification System to Assess the Crystallization Tendency of Organic Molecules from Undercooled Melts

Baird, JA, Van Eerdenbrugh B, Taylor LS

 

 

2013      

Effects of Uremic Toxins on Transport and Metabolism of Different Biopharmaceutics Drug Disposition Classification System Xenobiotics

Reyes M, Benet LZ

 

 

2014      

Relationship Between Potential Aggregation-Prone Regions and HLA-DR-Binding T-Cell Immune Epitopes: Implications for Rational Design of Novel and Follow-on Therapeutic Antibodies

Kumar S, Mitchell MA, Rup B, Singh SK

 

2015     

Development of a Human Antibody Tolerant Mouse Model to Assess the Immunogenicity Risk Due to Aggregated Biotherapeutics

Bi V, Jawa V, Joubert MK, Kaliyaperumal A, Eakin C, Richmond K, Pan O, Sun J, Hokom M, Goletz TJ, Wypych J, Zhou L, Kerwin BA, Narhi LO, Arora T