Author Guidelines

Author Guidelines



The Annals of Neurology publishes articles of broad interest in neurology, particularly those with high impact in understanding the mechanisms and treatment of diseases of the human nervous system. Although Annals publishes papers using a wide variety of clinical and basic neuroscience methods, we are most interested in those manuscripts that will be of general interest to academic neurologists, including clinical trials and other large-scale studies that inform the practice of medicine. Purely basic studies, without strong clinical or translational potential, are unlikely to have sufficient priority for publication


Editorial Office and Reviewing Editor Information


All papers at Annals of Neurology are previewed by the Editor-in-Chief and an Associate Editor.  Those papers that potentially have sufficient novelty and impact for publication are then sent to reviewers, and the rest are returned without review, usually in about 1-2 weeks. Once reviews are received, papers are considered at the weekly Editorial conference by all of the Editors, and authors are informed of their decisions.  The mean time to making a decision on a new paper is about 5 weeks, but please permit up to 8 weeks before inquiring about the status of your paper.


For all new manuscripts, authors should indicate their preferences among the Associate Editors, whose names and specialties are listed below:


Clinical trials, Pediatric Neurology

Associate Editor: Erika Augustine MD, MS




Dementia and Behavioral Neurology

Associate Editor: David M. Holtzman, MD
Assistant Editor: Erik Musiek, MD, PhD




Epilepsy, Sleep and Neurophysiology

Associate Editor: Amy R. Brooks-Kayal, MD
Assistant Editor: Nigel P. Pedersen, MD




Movement Disorders

Associate Editor: Deborah A. Hall MD, PhD
Assistant Editor: Kathleen L. Poston, MD MS




Neurogenetics, Developmental Disorders

Associate Editor: Elizabeth Engle, MD





Associate Editor: John R. Corboy MD
Assistant Editor: Erin Longbrake, MD, PhD




Neuromuscular Disorders

Associate Editor: Merit E. Cudkowicz MD, MSc
Assistant Editor: Reza Seyedsadjadi, MD




*Vascular Neurology & Teleneurology

Associate Editor: Lawrence R. Wechsler MD
Assistant Editor: Marcelo Rocha, MD, PhD





Associate Editor: Eva L. Feldman, MD, PhD




Statistical Editor

Rebecca A. Betensky, PhD


Managing Editors


Robert G. Kowalski, MD, MS


Daniel Roe, PhD


Editorial Policies 

1. Submission and Review Process

- Authors are required to submit manuscripts through our online submission website. If for any reason you are unable to do so, please contact the Managing Editor to discuss the possibility of alternate arrangements

- Submissions must not be under consideration by any other journal or published previously (apart from abstracts).

- All submissions are thoroughly vetted by Editors prior to peer review. Because Annals can only publish a small percentage of the papers we receive, our Editors only send out for review those papers that they feel have sufficient priority that they will have a reasonable chance of being published. However, fewer than half of papers sent for review can be published, so an invitation to revise your manuscript is not a guarantee of acceptance for publication.

- The Annals is committed to providing a timely decision for every submission we receive. To accomplish this, we strictly enforce time limits for peer review and for editorial consideration.If authors require a decision within a restricted time frame (because of a competing paper from another group or similar problem, but NOT to meet a grant or promotion deadline), please contact the Managing Editor at [email protected].

- To ensure your communications are properly routed to the appropriate Editors, all correspondence regarding your submission must be directed to the Managing Editor, at [email protected]. Do not contact the Editor-in-Chief, Associate Editors, or members of the Editorial Board.

All ANA Fellows now receive one guaranteed review per year. If you are the first, senior or corresponding author on a manuscript you will be asked whether you would like the submitted paper to receive a guaranteed review.

Please note the following:

  • One paper per year for external review
  • You must be first, last, or corresponding author
  • Your dues must be paid in full for the year
  • Acceptance is not guaranteed
  • Your paper may be recommended for transfer to our sister journal Annals of Clinical and Translational Neurology (ACTN)



2. Conflict of Interest Disclosure:

- An ICMJE conflict of interest form must be completed by each author. The Annals is in compliance with the International Committee of Medical Journal Editors (ICMJE) recommendations regarding conflicts of interest. Relevant information and a copy of the necessary information and the ICMJE disclosure form can be obtained here:

- In addition, there must be a section of the text, after the body of the text but before the References, labeled “Potential Conflicts of Interest”. This should contain a succinct summary of all commercial relationships of any author with a company whose product is used in the study or may be affected by its outcome. Please do not include relationships with non-profit or governmental bodies, or commercial relationships that are not of direct relevance to the current research.  For each potential conflict, please identify why the conflict exists (e.g., not “Dr. A is a consultant to Company X” but “Dr. A receives consultant fees from Company X, which manufactures the drug that is tested in this study.”

- Failure to disclose information in the ICMJE forms or in the Potential Conflicts of Interest section of the text will be grounds for immediate rejection of a manuscript. Additional sanctions, at the discretion of the Editors, may be undertaken for repeat offenders.



3. Experimental Studies of Human Subjects:

- The Methods section of the manuscript must contain a statement verifying that the protocol for the study has received prior approval by the appropriate Institutional Review Board, and that informed consent was obtained from each subject. A copy of the IRB approval must be provided if it is requested.

- Clinical trial reports must be written in accordance with the CONSORT reporting guidelines. (Download PDF file - 110K).

- All clinical trials must be registered in a database that meets the requirements set forth by the ICMJE: (1) The registry must be publicly accessible. (2) It must be open to all registrants and managed by a not-for-profit group. (3) The registry must have a mechanism to guarantee accuracy and validity of the information submitted.(4) The registry must adhere to the ICMJE mandates described in the table found on their website: Additional information can be found here:  Endpoints in the paper should be those in the registration.  If other endpoints are used, this should be pointed out and the reasoning discussed in the text.



4. Animal Experiments. The Methods section must contain a statement verifying that the protocol for the study has received approval by the Institutional Animal Care and Use Committee, and that all studies were conducted in accordance with the United States Public Health Service's Policy on Humane Care and Use of Laboratory Animals. A copy of the IACUC approval must be provided if it is requested.

5. Sharing of Data and Reagents.
Authors will be required following publication to make available any new nucleic acid constructs, recombinant organisms, antibodies, or other unique reagents and to make their data available to other investigators for the purpose of verifying and replicating results. The Editors strongly encourage authors to make their data available to other investigators for other purposes, e.g. to deposit microarray data in a public repository, such as GEO or ArrayExpress.

6. One author must be designated when the paper is uploaded to the ManuscriptCentral website as corresponding author for the purpose of being the point person for dealing with the Editors. It is understood that this person will communicate with the other authors and serve as the main contact person for the group. In addition, the manuscript should designate on its Title Page, a “corresponding author” who will be the person who will be responsible for answering questions about the paper once it is published. These need not be (and frequently are not) the same person. The “corresponding author” in the final paper should be a member of the team who is well established in the field and likely to remain in the field and to maintain contacts with the other authors, because questions about the paper may occur many years in the future. In some limited cases, it may be necessary to name more than one “corresponding author” for this purpose, e.g., if the two “corresponding authors” represent very different areas of expertise, and would find it difficult to answer questions in the other’s domain.

7. Nonhuman artificial intelligence, language models, machine learning, or similar technologies. Artificial intelligence generated content (AIGC) tools—such as ChatGPT and others based on large language models (LLMs)—cannot be considered capable of initiating an original piece of research without direction by human authors. They also cannot be accountable for a published work or for research design, which is a generally held requirement of authorship (as discussed in the previous section), nor do they have legal standing or the ability to hold or assign copyright. Therefore—in accordance with COPE’s position statement on AI tools—these tools cannot fulfill the role of, nor be listed as, an author of an article. If an author has used this kind of tool to develop any portion of a manuscript, its use must be described, transparently and in detail, in the Methods or Acknowledgements section. The author is fully responsible for the accuracy of any information provided by the tool and for correctly referencing any supporting work on which that information depends. Tools that are used to improve spelling, grammar, and general editing are not included in the scope of these guidelines. The final decision about whether use of an AIGC tool is appropriate or permissible in the circumstances of a submitted manuscript or a published article lies with the journal’s editor or other party responsible for the publication’s editorial policy.

8. Disclosure of algorithms utilized in machine learning or artificial intelligence technology. Manuscripts utilizing machine-learning or deep-learning algorithms should provide sufficient detail about the algorithm to allow replication of the manuscript’s results.

9. Data Sharing. For research reports, authors must provide a Data Sharing Statement indicating whether data will be shared, or not shared. The authors’ decision on whether to share data will be published in a Data Sharing Statement in an online supplement linked to the published article. In this statement authors will be asked to identify the relevant data, including individual patient-level data, a data dictionary that defines each field in the data set, and supporting documentation (eg, statistical/analytic code), that will be made available to others. The Data Sharing Statement must also specify when, where, and how the data will be made available to requestors (i.e., a link to a data repository); types of analyses that are permitted; and if there will be any restrictions on the use of the data. Authors will have the option to explain why certain data related to a manuscript is not being shared.

Manuscript Submission Information

Submission requirements for the Annals of Neurology are in accordance with the ICMJE Uniform Requirements. Please review the following document prior to submission of your manuscript:

Submit your manuscripts online at where you and your coauthors may view the status of your manuscript as it progresses through the review process.  Notification of the disposition of each manuscript will be sent by e-mail to the submitting author on the day of decision. 


Cover letter: At minimum, please include all of the following elements in your cover letter to the editors: 1) type of submission (Research Article, Brief Communication, etc.), the corresponding author complete with a mailing address, telephone and fax numbers, and an e-mail address, 2) a statement certifying that all coauthors have reviewed and approve the contents of the manuscript, that the Annals of Neurology (77:187, 2015) requirements for authorship have been met,, 3) certify that the submission (aside from an abstract) is not under review at any other publication,4) a full statement about all submissions and previous reports that might be regarded as overlapping with the current work (any such work should be referred to specifically and referenced in the new paper), 5) a statement of financial or other relationships that might lead to a perceived conflict of interest


Important: If you have any related articles in-press or under review with another journal, please upload these files and designate them as "supplementary material not for review" when prompted. The editorial staff will have access to these files, but reviewers will not


Credits and Permissions
: Upon acceptance, we will require (1) notice of informed consent; (2) releases to publish photographs of recognizable persons; (3) written permission to use non-original material (including quotations exceeding 100 words or any table / figure) from both author and publisher of the original material; (4) written permission to name any individual acknowledged in the manuscript but not credited as an author. No article will be published without all required permissions.



Types of Manuscripts

Annals of Neurology publishes the following types of articles:



Research Articles: Research articles are papers reporting the results of original research. Articles are limited to 500 words for the Introduction, 1,500 words for the Discussion, and 4,500 words, 50 references, and eight figures or tables overall. We ask authors to be parsimonious in wording their Methods and Results sections, referring to other papers, when possible, for methodological details, and to not describe Results in detail that are clearly shown in a table or figure.



Brief Communications: Brief Communications should be limited to 1,500 words, with 20 references or fewer, and no more than a total of three tables or illustrations. Annals rarely publishes case reports, unless they definitively identify a new mechanism of disease or treatment.



Letters to the Editor and Replies: Letters should be limited to 400 words and may include one table or figure, if essential, and five or fewer references. Only letters addressing previously published articles will be considered. Letters are not an appropriate way to report new research unless it bears directly on the results of a previously published article.




Review Articles: Review articles are broadly based and are meant to cover an important field of neurology in an authoritative way. Reviews are usually invited from individuals who are experts in a field, who are encouraged to contact the Editor-in-Chief.  Reviews should contain approximately 5,000-6,000 words and 100-125 references spanning recent advances in the field. Please address presubmission inquiries to our review editor Eva L. Feldman, MD, PhD at [email protected].



Neurology Grand Rounds: Neurology Grand Rounds are a new feature, meant to recreate the type of presentation that is generally given by an invited speaker in a Grand Rounds series at a major academic medical center. Grand Rounds presentations can be Clinico-Pathology Conferences, or they may present a point of view from a single author or group of authors. The material should focus on the thesis of the presenter, and need be not as broadly based and representative of the field as a typical Review article. Grand Round articles should otherwise follow the same guidelines as Reviews for the length of the article and number of references.



NeuroGenesis Articles: The NeuroGenesis series is meant to focus on issues concerning the development of the careers of academic neurologists. Recent contributions have ranged from the decision to enter neurology residency through social networks among previous presidents of the AAN and ANA. NeuroGenesis articles should be limited to 1,500 words and 20 references.



Editorials and Commentaries: Commentaries are invited discussions of new papers, and are usually published in the same issue as the target article. Editorials are short opinion pieces concerning issues facing modern academic neurology. Both types of articles are generally invited, and those who seek to write them are encouraged to contact the Editor-in-chief. Editorials and Commentaries should be less than 1,000 words.



Neuro-Images: This feature centers on a visual image depicting an interesting or unique neurological observation. Images may include MRIs (magnetic resonance images), CTs (computed tomography), PET (positron emission tomography) scans, SPECT (single-photon emission tomography) scans, angiograms, patient photographs (de-identified if possible), deep brain stimulation electrode reconstructions, or other appropriate visual images. Images should be submitted as a single figure, but this figure may include multiple panels. A figure caption describing the image, clinical presentation, neurological findings, and broader relevance should be included. The caption should be no more 500 words and include no more than 4 references. There is no abstract. The title for the submission should consist of no more than eight words and the submission should include no more than 4 authors.

Videos can also be referenced, and will be treated as supplementary files as they are for any Annals paper, but there must be at least one static image that is publishable in the journal. For visual images taken from a larger 3D volume (e.g. single slices from an MRI scan), we encourage links to the full de-identified 3D image on public resources such as Neurovault (  



Organization of the Manuscript:


Coversheet: The first page of every submission should contain all of the following information: (1) title and running head; (2) all authors’ names, degrees and affiliations; (3) corresponding author’s contact information; (4) number of characters in the title and running head; (5) number of words in the Abstract, Introduction, Discussion and the body of the manuscript (not including abstract or references, figure legends, etc.); (6) number of figures, color figures, and tables. (Gathering this information ahead of submission will greatly facilitate the online submission process.)



Title: Titles should be short, specific, and clear. Do not use abbreviations in the title.



Running head: Please provide a running head title for your submission. Do not exceed 50 characters.




Authors: Individuals should be listed individually as authors only if they have contributed to one of the 3 key contributions that justify authorship, listed below in the discussion of "Authorship." Individuals who have participated in large, multi-center studies and who have played an important role in the data collection and analysis of individual patients may be recognized on the Author line of the manuscript as part of a Group related to that study (e.g., Alzheimer Disease Neuroimaging Initiative, Parkinson Study Group, etc.). The composition of the Group should then be acknowledged by a paragraph in the Author Contributions section a table listing the participants and their affiliated institutions. If the study group has more than 15 participants, this information should be gathered in a Supplementary Table, and the Authorship Contribution should direct the reader to the table for information about the Study Group members and affiliations



All author names should include first name, middle initial (if provided), last name, and degrees. Author affiliations should be indicated by using superscript numbers. Affiliations are specific to the department level: two authors at one institution but in different departments have separate listings; two authors in the same department will have one affiliation. Statements of equal authorship contribution may be included. At least one person’s name must precede a Group-attributed authorship (e.g. “Robert R. Jones for the Meningitis Study Group”).



A paragraph should be included at the end of the manuscript, indicating the contribution of each author to the study.



Each named author must file a copy of the Conflicts of Interest form by the International Committee of Medical Journal Editors. A paragraph should be included at the end of the manuscript describing any relevant conflicts of interest for each author. Note that a relevant conflict is one that could bias that author in the conduct of the reported work. Corporate financial relationships that are not relevant to the work should not be listed here, although they should be included in the ICMJE form




Summary for Social Media: Please add a page between the title page and the Abstract, called Summary for Social Media If Published, and provide the information below:



  1. If you and/or a co-author has a Twitter handle that you would like to be tagged, please enter it here. (format: @AUTHORSHANDLE).
  2. What is the current knowledge on the topic?  (one to two sentences)
  3. What question did this study address? (one to two sentences)
  4. What does this study add to our knowledge?  (one to two sentences)
  5. How might this potentially impact on the practice of neurology? (one to two sentences)



If your paper is accepted, our Social Media Editor may decide to Tweet about it or otherwise promote your work, and we encourage you to do the same. You may also submit a draft Tweet of no more than 180 characters that conveys the essential message of your paper, which the Social Media Editor will consider and possibly post to @ANA_Journals on Twitter.




Abstracts: The second page should contain the Abstract. Abstracts should not contain abbreviations or references. Abstracts for Research Articles must be limited to 250 words and must be structured into subsections for: Objective, Methods, Results, Interpretation. Abstracts for Reviews, Neurology Grand Rounds, Neurogenesis, or Brief Communications, Abstracts are limited to 100 words and should not include subsections



Abbreviations: Always spell out abbreviations at first mention, and place the acronym or abbreviation in parentheses immediately after. Abbreviations should be limited to terms that are both long and frequently repeated in the text. Try to avoid using more than six abbreviations in a paper, least the text appear to be written in code.



Text for Research Articles and Brief Communications: Sections must appear in the following order: Abstract, Introduction, Methods, Results, Discussion, Acknowledgements, Author Contributions, Conflicts of Interest, and References. This should be followed by Figure Legends, and then any Tables. Acknowledgements should include individuals who have contributed to the work (provided materials, technical assistance, etc.), but are not authors but all such individuals should agree to being included in this way before the manuscript is submitted. The Acknowledgements should also include sources of financial support for the work.



The main body of all manuscripts, and all tables included with your submissions must be provided in Microsoft Word .DOC format.



All manuscripts published in Annals of Neurology must have sections for Acknowledgements, Author Contributions, Potential Conflicts of Interest, and Data Availability, in that order as described below:

Acknowledgements: The authors may BRIEFLY state their thanks to individuals who may have helped. Sources of research funding should also be acknowledged.



Author Contributions: Following the Acknowledgements, list the initials of the authors who have contributed to at least one of the key contributions that justify authorship, including 1) conception and design of the study, 2) acquisition and analysis of data or 3) drafting a significant portion of the manuscript or figures (i.e., a substantial contribution beyond copy editing and approval of the final draft, which is expected of all authors). Individuals who contributed data acquisition (including phenotyping and gathering information on patients) but not to the final analysis that is unique to this manuscript (e.g., site investigators in a large clinical trial or contributors to a large patient database) may be included within a Study Group, which may be mentioned collectively on the author line. In that case, the members of the group and their affiliations should be listed in a separate paragraph under Author Contributions. If there are more than 15 authors in the Study Group, the Study Group members and affiliations should be placed in a supplementary file, which should be indicated in the Author Contributions section instead. Individuals who did not fulfill one of these key roles, or who made purely technical contributions, should not be authors, but rather should be acknowledged.




Potential Conflicts of Interest: List any real or apparent conflicts of interest of any of the commercial relationships of the authors with the material presented in the paper, and describe briefly what the conflict is (i.e., do not just write "Author AB has been a consultant for XY Corporation," but instead "Author AB has been a consultant for XY Corporation, which owns patent rights to drug Z that was used in this study.")  Do NOT list irrelevant commercial interests of authors, as these just take up space in the journal, and serve to obscure the important relationships. All commercial interests of all named authors should however be included in the ICMJE Conflict of Interest forms filed for each author. If authors feel that they have no potential conflicts of interests relevant to their manuscript then they may simply state "Nothing to report."




Data Availability: The Editors require authors to provide a data availability statement (simply named "Data Availability" and appearing after "Potential Conflicts of Interest") and to make their data available to other investigators for the purpose of replication and re-use. Exome, genome, epigenetic, and microarray data must be deposited in a public repository such as the NIH's Gene Expression Omnibus ( GEO) or the European Molecular Biology Laboratory-European Bioinformatics Institute's (EMBL-EBI) ArrayExpress.




References: List up to four authors; if more than four, list three and "et al". Arrange in order of citation, and cite all references by number in the text, superscript and without brackets. Please check all references for errors of citation or attribution.Unpublished data, which include articles submitted, but not in press, and personal communications must be given in parentheses in the text, not as references.


Sample journal reference: Ahn S, Riccio A, Ginty DD. Spatial consideration for stimulus-dependent transcription in neurons. Annu Rev Physiol 2000;62:803-823



Sample book reference: Volpe JJ. Neurology of the newborn. 4th ed. Philadelphia: Saunders, 2001.


Sample reference to electronic content using DOI: Fisher E, Lee J-C, Nakamura K, et al. Gray matter atrophy in multiple sclerosis: a longitudinal study. Ann Neurol 2008;DOI:10.1002/ana.21436


Figure Legends:Type on pages separate from the text and figures. Provide one legend for each figure, and number legends in sequence. For photomicrographs, indicate the stain and use an internal scale marker.


Figures: Figures should be cited in order of appearance. Please do not repeat figure callouts more than twice in a paragraph. Place callouts in parentheses: (Fig 1), (Fig 1 and 2), (Fig 1-4), (Fig 1A to C).All panels in all figures should be identified by unique panel designators (A, B, C…). If two or more images appear in a single panel, each should be clearly indicated by distinct labels.  Panels should be separated from one another by 2 mm of white space.  The figure should be in either single column (8 cm) or full page (17 cm) width format, at 300 dpi of resolution.  Please keep figures in portrait orientation.  Single-column width artwork is preferred; please stack figure panels vertically whenever possible


All figures must be submitted in TIFF format. Do not submit your figures embedded in a Microsoft Word or Adobe PDF document (i.e., as a .DOC or a .PDF file). JPG, GIF, EPS, PSD, CRD, PCT, PPT, PDF, XLS, BMP, or other formats are all unacceptable.


Color Figures: Color figures should be submitted in RGB colorspace. Do not submit color figures as CMYK.


To ensure consistency between figures and legends, and to preserve conformity and neatness in style, please be sure your figure panels are labeled in uppercase letters (A, B, C, etc.) using a sans serif font (e.g. Helvetica).The font size should measure 9 points (3 mm height) after the figure is reduced to the appropriate dimensions (8cm or 17cm width). Any text within a figure (e.g. the axes of a graph) should be 6 points (2 mm height) after final reduction.


To create high resolution figures from Microsoft PowerPoint or Excel, you will have to (1) export the figure to a Post Script file (this is done through the print menu and requires Adobe Acrobat Professional); (2) using Adobe Photoshop, open the figure in 300, 600, or 1200 dpi resolution and RGB colorspace; (3) using the image size tool, adjust the dimensions of the figure to a maximum width of either 8cm or 17cm across; (4) save the file as a TIFF.

Please do not include extra text (including keys and headings) in the artwork; spell out keys and headings in the figure legend instead.Photographs of recognizable persons should be accompanied by a signed release from the patient or legal guardian authorizing publication. Masking eyes to hide identity is not sufficient.



The charge to authors for color figures that are printed in the journal is $650 for the first page of color and $400 for each additional page containing color illustrations. Color prints should contain any necessary internal labeling (e.g., arrows, bars). Color is available in the on-line version of the Annals without charge if a black and white version of the same figure is provided by the authors for the print journal.  In this case, the text and figure legend must not refer to the color in the image, and the point of the image must be clear in the black and white version (e.g., lines or bar graphs can be of different density or shading to distinguish them).


Tables: Tables should be printable in a single page in portrait orientation. They should be typed in the same font as the rest of the paper, as text tables (rather than as figures). Tables should be numbered in order of appearance in the text. Please do not repeat table callouts more than twice in a paragraph. Place callouts in parentheses: (Table 1), (Tables 1 and 2), (Tables 1-4). Please do not embed your tables in the main .doc file. Instead, give each table its own .doc file following the main .doc file. Data in tables should not duplicate material in the text or illustrations


Graphical Abstracts: We now encourage authors to submit a graphical abstract to complement their paper. These graphics are published in the online issue of the journal within the Table of Contents and in the HTML version of the paper and may be used in social media promotion.


Images for the graphical abstract should capture the essence of a paper, displaying a figure, plot, or scheme that is central to the theme of the manuscript.  Color images are strongly encouraged. If you are unfamiliar with graphical abstracts, Wiley Editing Services provides examples and offers Graphical Abstract Creation Services for a fee:


Another service available to authors is:


Alternatively, you are welcome to submit one of your own creation using the guidelines below:


Images can be formatted as either 55 mm wide X 50 mm high or 110 mm wide X 20 mm high.


For bitmap images, a 55 mm X 50 mm image should be 650 pixels wide while a 110 mm X 20 mm image should be 1300 pixels wide.


Both bitmap and vector graphics images should be prepared with labels using a font at least 10 points in size.


The use of insets in Table of Contents images is discouraged, as the data in the inset may be difficult to read.


Please include an 80-words abstract summarizing the key findings presented in the paper to accompany the image.


When you resubmit your manuscript, please upload your graphical abstract as supplementary material with a filename indicating clearly what it is (e.g., “graphical_abstract_ANA-22-XXXX.png,”).


Please note that a graphical abstract is in addition to the regular abstract, it does not replace the abstract (nor does it replace or duplicate a figure).


Supplementary Materials: Annals of Neurology now supports supplementary materials. We encourage authors to place copies of red-green figures using magenta-green coloring in the supplementary material for readers who are red-green color blind (about 6% of male readers). To do this, in Photoshop, click on the Channels Palette, then the Red Channel. Select the entire image, then Copy. Then click on the Blue Channel, and Paste. When you now click on the RGB image, the red will be replaced by magenta, which red-green color blind individuals can distinguish from green.


Online Submission: Please review these instructions carefully and take note of further instruction provided at the top of each screen of the seven-stage submission process. Submit your manuscript and all figures, tables, and supplementary materials exactly as instructed to avoid a delay in processing your manuscript.


Log in to our submission site and access your Author Center. If you do not already have an account, please create an account for yourself by clicking on the "Create an Account " button. If you have forgotten your password, enter your email address in the field provided on the login screen and click “go” to have your account information emailed to you.


To submit a new manuscript, click the indicated link on the main screen.


To submit a revision, click “Manuscripts with Decisions” and click on the link located to the right of your manuscript title. Prior to submitting your revision, please review the attachment provided with your most recent decision letter from the Managing Editor.


1. Select a Manuscript Type, enter title, running head, and abstract. Enter “none” in the abstract field for letters and other manuscript types that do not require an abstract.  Be sure to respond to all fields marked with a purple “req,” which denotes a required field.  Manuscript submission will fail if any required field is left blank.  Click Next to proceed to step 2.


2. Please select the most appropriate “domain” for your manuscript. This is simply used by the Editorial staff to help identify the most appropriate Associate Editor, and has no further bearing on your manuscript. Enter at least one “keyword” associated with the subject or methods of your submission. Click Next to proceed to step 3.


3. Enter all authors' names and contact information. Click Next to proceed to step 4.


4.Identify potential reviewers and preferred non-reviewers. E-mail addresses are essential for this optional step. You may opt out of recommending preferred or non-preferred reviewers, and there is no guarantee the Editors will follow your recommendation. Click Next to proceed to step 5.


5. Paste or attach a Microsoft Word copy of your cover letter. Enter all manuscript metadata (number of pages, number of words in the body of the text, number of tables, etc.) making sure this information matches the information captured on your coversheet. Enter any previously assigned Manuscript IDs, if applicable.Click Next to proceed to step 6.


6. Your main document, figures, and supplementary material files may be uploaded in batches of five files. After the first five are uploaded, you will be able to upload five more, and so on.Please be sure to enter any figure legends, and name your figures as they are named in the text when prompted after uploading your figure files. A separate conflict of interest form is required for each author. The form can be obtained here:


Do not submit any signed copyright transfer forms to the editorial office during the submission process. Please also remember that offline submissions will only be considered in exceptional circumstances, and must be agreed upon with the Managing Editor in advance of submission.Click “Next” to proceed to the final step.


7. The appearance of any red “X” indicates a required field was left blank in the submission process. The manuscript cannot be submitted until all required information is provided. Please carefully review your proofs in both HTML and PDF format. If you notice any problems, please contact the Managing Editor: [email protected]. Do not be alarmed if your figures appear small in the HTML proof. The “Image Spy” link below the figure may be used to zoom in to maximum figure dimensions.Click the blue “Submit” button to submit your manuscript. At the end of a successful submission, a confirmation screen with your manuscript number will appear and you will receive an E-mail confirming that the manuscript has been received by the Journal. If this does not happen, please check your submission in your Author Center and/or contact the Managing Editor.


Annals of Clinical and Translational Neurology


Because Annals of Neurology does not have space to publish all of the high quality papers that we receive, the American Neurological Association has established a sister journal, Annals of Clinical and Translational Neurology. This is an Open Access journal, specifically designed to enable rapid publication of high quality research that we cannot offer publication in Annals of Neurology. Authors of such papers will be offered the option of having the paper, along with any related peer reviews, automatically transferred for consideration by the Editor of Annals of Clinical and Translational Neurology. Authors will not need to reformat or rewrite their manuscript at this stage, and publication decisions will be made a short time after the transfer takes place. Annals of Clinical and Translational Neurology is an Open Access journal and article publication fees apply. For more information on this journal’s APCs, please see the Open Access page.



Authors will receive an e-mail notification with a link and instructions for accessing HTML page proofs online/with their proofs included as a pdf. Authors should also make sure that any renumbered tables, figures, or references match text citations and that figure legends correspond with text citations and actual figures. Proofs must be returned within 48 hours of receipt of the email. Email your e-annotated proofs and forms to:


ANA Production

E-mail: [email protected]


For additional tools visit Author Resources - an enhanced suite of online tools for WIley InterScience journal authors, featuring Article Tracking, E-mail Publication Alerts and Customized Research Tools.

Copyright and Online Open

If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper.


For authors signing the copyright transfer agreement


If the open access option is not selected the corresponding author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:


CTA Terms and Conditions


For authors choosing open access: If the open access option is selected, the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA): Creative Commons Attribution Non-Commercial License OAA or Creative Commons Attribution Non-Commercial -NoDerivatives License OAA


To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit


If you select the open access option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK requirements. For more information on this policy and the Journal’s compliant self-archiving policy please visit:


For RCUK and Wellcome Trust authors click on the link below to preview the terms and conditions of the Creative Commons Attribution License OAA


To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services Services and visit

bauthor/faqs_copyright.asp and visit