CTI Special Feature on Endoplasmic Reticulum and Oxidative Stress in Immunopathology

Special Feature Coordinator: Sumaira Z Hasnain

Endoplasmic reticulum (ER) stress and related molecular programs, which occur when proteins misfold during biosynthesis in the ER, are important components of the pathophysiology of several diseases including cancer, diabetes, inflammatory bowel disease and multiple forms of respiratory inflammation. Despite this, our understanding of the molecular programs that regulate ER stress, ER-associated degradation pathways, oxidative stress and the unfolded protein response are limited. In this Special Feature of Clinical & Translational Immunology, we highlight the complex relationship between cellular stress pathways and inflammation and the potential strategies that could pave the way for specific drugs designed to improve protein folding, manipulate the unfolded protein response to reduce inflammation and restore homeostasis.

EDITORIAL

Endoplasmic reticulum and oxidative stress in immunopathology: understanding the crosstalk between cellular stress and inflammation
Sumaira Z Hasnain
Clin Trans Immunol 2018, 7: e1035.
Full Text | PDF



REVIEWS

Oxidative and endoplasmic reticulum stress in respiratory disease
Alice C‐H Chen, Lucy Burr, Michael A McGuckin
Clin Trans Immunol 2018, 7: e1019.
Abstract | Full Text | PDF

Recent novel approaches to limit oxidative stress and inflammation in diabetic complications
Raelene J Pickering, Carlos J Rosado, Arpeeta Sharma, Shareefa Buksh, Mitchel Tate, Judy B de Haan
Clin Trans Immunol 2018, 7: e1016.
Abstract | Full Text | PDF

Endoplasmic reticulum stress in the development of multiple myeloma and drug resistance
Nicholas Nikesitch, James M Lee, Silvia Ling, Tara Laurine Roberts
Clin Trans Immunol 2018, 7: e1007.
Abstract | Full Text | PDF

The role of IL‐22 in the resolution of sterile and nonsterile inflammation
Saleh Y Alabbas, Jakob Begun, Timothy H Florin, Iulia Oancea
Clin Trans Immunol 2018, 7: e1017.
Abstract | Full Text | PDF

Immune regulation of the unfolded protein response at the mucosal barrier in viral infection
Ran Wang, Md. Moniruzzaman, Eric Shuffle, Rohan Lourie, Sumaira Z Hasnain
Clin Trans Immunol 2018, 7: e1014.
Abstract | Full Text | PDF