• Issue
    Volume 17, Issue 1
    January 3, 2022

Cover Pictures

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Front Cover: Asymmetric Total Syntheses, Stereostructures, and Cytotoxicities of Marine Bromotriterpenoids Aplysiol B (Laurenmariannol) and Saiyacenol A (Chem. Asian J. 1/2022)

  • First Published: 09 December 2021
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Total assignments of stereostructures of marine cytotoxic bromotriterpenoids, aplysiol B (laurenmariannol) and saiyacenol A derived from a sea hare or red alga, have been accomplished through their asymmetric syntheses from the known epoxide to elucidate their ambiguous stereostructures. The two molecules reflected on the water surface in the cover image represent the proposed structures for aplysiol B and laurenmariannol, respectively, and the highlighted asymmetric centers show revised and elucidated positions. The escaping fish are illustrating the feeding deterrence property of aplysiol B. More information can be found in the Communication by Keisuke Nishikawa, Yoshiki Morimoto et al.

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Cover Feature: Ag(I)-Catalyzed/Acid-Mediated Cascade Cyclization of ortho-Alkynylaryl-1,3-dicarbonyls to Access Arylnaphthalenelactones and Furanonaphthol Libraries via Aryl-Disengagement (Chem. Asian J. 1/2022)

  • First Published: 09 December 2021
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The diverging path: The artwork in the cover depicts the use of ortho-alkynylarylketones with a 1,3-dicarbonyl pendant for the synthesis of arylnaphthalenelactone and furanonaphthol libraries. The method utilized a silver catalyst to promote the decarboxylative cyclization in one pot to vastly improve access to arylnaphthalenelactones. For ketone substrates containing a 2-chloro-4,6-dimethoxybenzene substituent, the reaction diverged into the novel oxy-dearylation reaction to form furanonaphthols. The method was general and applicable to a wide range of substrates. More information can be found in the Research Article by Jumreang Tummatorn et al.

Editorial

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Board, Awards and other news

  • First Published: 22 December 2021
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In her editorial, Editor-in-Chief Theresa Kueckmann welcomes new members to the Editorial Board (see image), International Advisory Board, and Early Career Advisory Board, reflects on recent symposia and achievements at the three ACES journals, and announces some editorial changes that were recently launched to serve authors and readers better.

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In Celebration of the 65th Birthday of Professor Andy Hor

  • First Published: 20 December 2021
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Metals are involved in various research fields of chemistry where they play key roles, as illustrated for example in transition-metal homogeneous catalysis, materials for energy storage and conversion, luminescent materials, and coordination-driven self-assembly. This special collection of Chemistry – An Asian Journal features significant contributions that chemists around the world make in this area. Working together with Professors Pierre Braunstein, Chi-Ming Che, Guo-Xin Jin, Fuwei Li and Yun Zong, Chemistry – An Asian Journal assembled 56 excellent contributions in this special collection to celebrate the 65th birthday of Prof. Andy Hor (A*STAR, Singapore).

Minireviews

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Two-Dimensional Halide Perovskites: Approaches to Improve Optoelectronic Properties

  • First Published: 05 November 2021
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The current review focuses on various strategies adopted so far in 2D perovskites to reduce the exciton binding energy and enhance the charge-carrier dissociation efficiency. Improved optoelectronic properties were realized by tuning the quantum and dielectric confinements, crystallographic orientation, interlayer distance, and introducing functional organic cations, charge transfer complexes, and conducting polymers into the perovskite structure.

Reviews

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Cyclopentadienyl Complexes of the Alkaline Earths in Light of the Periodic Trends

  • First Published: 25 November 2021
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Structurally well-defined cyclopentadienyl complexes of the five alkaline earths from beryllium to barium are reviewed with an emphasis on their periodic trends.

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Recent Developments in the Chemistry of Pn(I) (Pn=N, P, As, Sb, Bi) Cations

  • First Published: 16 November 2021
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The chemistry of Pn(I) cations, isoelectronic to donor-stabilized carbones is an emerging field in contemporary main group research. Strategic syntheses of Pn(I) cations involving strong σ-donor supporting ligands combined with their chelating effects have proven useful in enhancing the nucleophilicity despite inherent positive charge. Their unique bonding situations show potential applications in small molecule activation and catalysis.

Communications

Open Access

Asymmetric Total Syntheses, Stereostructures, and Cytotoxicities of Marine Bromotriterpenoids Aplysiol B (Laurenmariannol) and Saiyacenol A

  • First Published: 26 October 2021
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Total assignments of stereostructures of marine cytotoxic bromotriterpenoids, aplysiol B (laurenmariannol) and saiyacenol A, were accomplished through their asymmetric chemical syntheses to elucidate their ambiguous stereostructures and whether or not other members showing the opposite chirality for the ABC ring system exist. Moreover, their preliminary growth inhibitory activities against some tumor cells were also evaluated.

Full Papers

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Quinoline-cored Poly(Aryl Ether) Dendritic Organogels with Multiple Stimuli-Responsive and Adsorptive Properties

  • First Published: 02 November 2021
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Core quinoline-functionalized dendritic gelators have been synthesized for constructing smart and adsorptive organogel materials. These dendritic organogels exhibited smart multiple stimulus-responsive behaviors and excellent adsorption capacity for organic dyes and heavy metal ions.

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Visible-Light Photosynthesis of CHF2/CClF2/CBrF2-Substituted Ring-fused Quinazolinones in Dimethyl Carbonate

  • First Published: 26 November 2021
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A visible-light-enabled difluoromethylation and cascade cyclization alkenyl-substituted quinazolinones is accomplished by using cheap and readily accessible CXF2CO2H as the CXF2 source. A range of CHF2/CClF2/CBrF2-substituted ring-fused quinazolinones with important functional groups were obtained in high yields.

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Neutral 1D Perovskite-Type ABX3 Phase Transition Material with a Narrowband Emission and Semiconductor Property

  • First Published: 09 November 2021
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A 1D organic-inorganic perovskite of C5H6NOPbBr3 (1) which displays an interesting reversible phase transition at 250 K and exhibits excellent semiconductor performance (2.78 eV) is presented. It is worth noting that 1 shows a narrowband emission peak (FWHM=4.64 nm) at room temperature, which can be applied to narrowband photodetectors.

Research Articles

Very Important Paper

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Reversal of Solvatochromism: A New Strategy to Construct Activatable Two-photon Fluorescent Probes for Sensing

  • First Published: 09 November 2021
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Based on solvatochromism reversal, we here report a novel strategy to develop two-photon probes for bioimaging. Compared with normal two-photon probes that showed a fluorescence off with ICT suppressed, the novel probes exhibited strong fluorescence in aqueous solution when their ICT was inhibited.

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Enhanced Sieving of C2-Hydrocarbon from Methane by Fluoro-Functionalization of In-MOF with Robust Stability

  • First Published: 10 November 2021
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Reconstruction of a In-MOF with a fluoro-functionalized ligand can effectively enhance the separation capability for C2 hydrocarbon from methane.

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Ag(I)-Catalyzed/Acid-Mediated Cascade Cyclization of ortho-Alkynylaryl-1,3-dicarbonyls to Access Arylnaphthalenelactones and Furanonaphthol Libraries via Aryl-Disengagement

  • First Published: 11 November 2021
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ortho-Alkynylaryl-1,3-dicarbonyl derivatives were utilized for the synthesis of arylnaphthalenelactone via cascade cyclization/decarboxylation in one-pot. These classes of compounds showed good potency in inhibiting protein-tyrosine phosphatase 1B (PTP1B) enzyme.

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Catalyst-Controlled Regiodivergent Synthesis of α/β-Dipeptide Derivatives via N-Allylic Alkylation of O-Alkyl Hydroxamates with MBH Carbonates

  • First Published: 22 November 2021
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A catalyst-controlled switchable N-allylic reaction of O-alkyl hydroxamates with MBH carbonates is reported, providing a regiodivergent method for α/β-dipeptides derivatives.

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Nickel-Catalyzed Asymmetric Hydrogenation for the Synthesis of a Key Intermediate of Sitagliptin

  • First Published: 24 November 2021
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Sitagliptin intermediate, 3-R-Boc-amino-4-(2,4,5-trifluorophenyl)butyric ester, an antidiabetic drug candidate, has been synthesized using inexpensive, naturally abundant, sustainable nickel catalysis.

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Atom-economic Approach to the Synthesis of α-(Hetero)aryl-substituted Furan Derivatives from Biomass

  • First Published: 22 November 2021
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A combination of carbon-economic route (to integrate full HMF core) and atom-economic cycloaddition process (to avoid waste on the aromatic ring formation step) was implemented to access (hetero)aryl-substituted furan derivatives. The present study points out a possible direction to increase the synthetic potential of biomass processing in the preparation of fine chemicals and suggests a plausible connection with molecular electronics area.