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An HRL-SC/HIF-1α positive feedback loop enhances cell proliferation, migration and angiogenesis in dental pulp stem cells via PI3K/AKT signalling pathway

  • Version of Record online: 28 March 2025
An HRL-SC/HIF-1α positive feedback loop enhances cell proliferation, migration and angiogenesis in dental pulp stem cells via PI3K/AKT signalling pathway

Diagram showing that HRL-SC forms a positive feedback loop with HIF-1α and activates the PI3K/AKT signalling pathway through the integrin αvβ3/FAK and HIF-1α/PDK1 axes, thereby regulating the function of dental pulp stem cells.

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