A position paper, endorsed by the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility, focusing on transition care for adolescents and young adults transitioning from pediatric to adult healthcare settings.

This meta-analysis reveals that a significantly higher proportion of DGBI patients experienced deterioration of symptoms during the COVID-19 pandemic. Various sociocultural, economic and environmental factors potentially modify the effects of the COVID-19 pandemic on DGBI.

The straight leg raise (SLR) maneuver has been used as a method to assess esophagogastric junction (EGJ) competency during esophageal manometry. Several techniques involving the use of single or both legs have been used for SLR. Both the single and double leg raises were effective in detecting higher hiatal hernia in this study. Double leg raise was more effective in raising intraabdominal pressure by >50% compared to single leg raise. Encouraging patients to perform a double leg raise might facilitate more effective SLRs during HREMI.

In functional dyspepsia, the herbal preparation, STW5-II, improves GI symptoms, which may be related to disturbed GI motor functions. We characterized the effects of STW5-II on upper GI motor functions and established that it increases proximal gastric volume, reflective of reduced tone, and increases antral motility index, in healthy volunteers.

No antro-duodenal manometry parameters were identified to predict clinical response after G-POEM in refractory gastroparesis (GP) patients. A high percentage of abnormal ADM was found, in particular with relation to enteric dysmotility. Therefore, a more precise understanding of the pathomechanisms of GP is essential for the optimization of therapeutic strategies.

Acute administration of a combination of peppermint oil and caraway oil (POCO) does not affect the gastric function (gastric emptying and intragastric pressure [IGP]) in healthy subjects but improves symptoms after meal intake. Additionally, POCO increases subjective hunger sensations and decreases satiety, which can be a valuable asset for patients with functional dyspepsia who experience loss of appetite.

Using a double blind, cross-over, placebo controlled study design, STW-5 reduced abdominal symptoms induced by colonic gas filling in patients with IBS. The previously reported positive effects of STW-5 in patients with IBS could be related to an improved tolerance to colonic gas contents, by reducing sensitivity to colonic loads.

Our findings suggest DGBI pain symptoms are central and serve as a key connection to other symptoms, crosscutting anatomic location. Future longitudinal research is needed to test symptom network relations longitudinally and investigate whether targeting pain symptoms (rather than anatomic- or disorder-specific symptoms) has clinical impact.

In this double-blind, placebo-controlled crossover trial, an 8-mg dose of reboxetine substantially increased anal opening pressure in healthy women, suggesting it may benefit individuals with fecal incontinence. Conversely, a 40-mg dose of citalopram had a marginal and statistically insignificant effect on anal opening pressure, indicating that it does contribute to fecal incontinence by reducing anal sphincter tone.

This pilot study on the mechanism of chronic pain in inflammatory bowel disease (IBD) showed the difficulties with internet-based survey and how to tackle them. The preliminary results demonstrated that differences in symptoms and psychological characteristics exist between IBD patients in remission with and without abdominal pain exists.

A systematic, functional restoration approach to CBT for Pediatric DGBI significantly decreased abdominal pain and functional disability in this study; however, the response was less robust for patients higher in depressive symptoms and abdominal pain. These results suggest the need for additional research to improve CBT for youth with DGBI's.

Mesalamine significantly improved IBS symptoms as measured with the overall IBS symptom score in patients with postinfectious IBS diarrhea. Additionally, mesalamine improved anxiety and there was a trend towards improvement in all symptoms IBS and in QOL The long-acting mesalamine can have a role in the treatment of PI-IBS-diarrhea.

This large, US-based study explored the symptom burden, care-seeking behaviors, medication use, and overall satisfaction of symptom control among participants with CIC who met Rome IV criteria and emphasizes the need for better communication regarding prescription medications and their benefits, with the goal of further improving CIC patients' overall symptoms.

The phytomedicine STW 5 (Iberogast®) improves functional dyspepsia symptoms partly through proximal gastric relaxation. We found that STW 5 inhibited ORAI-coupled store-operated Ca²⁺ entry. This novel mode of action of a smooth muscle relaxing drug impact on design of drugs and approaches to treat motility disorders.

Primary polysaccharide characteristics of A. macrocephala polysaccharide (PAMK) was elucidated. PAMK significantly reduced the gastrointestinal transport time and increased the number of fecal pellets and fecal water content in spleen deficiency constipation model mice. PAMK kept the balance of 5-HT, SCFAs, TPH-1, SERT, chromogranin A (CgA) and neurotransmitter levels (vasoactive intestinal peptide (VIP), substance P (SP), motilin (MTL)) in mice colon. PAMK could regulate the abundance of gut microbiota such as Alistopes, Bacteroides, and Odoribacter in spleen deficiency constipation model mice gut.

We applied 16S rRNA gene sequencing and 1H nuclear magnetic resonance to investigate the differential pathways of different frequencies of electroacupuncture on the improvement of visceral pain. This study provides some evidence for the frequency dependence and potential mechanisms of the analgesic effects of electroacupuncture on chronic visceral pain.