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ISSUE INFORMATION
ISSUE INFORMATION - TOC
IN THIS ISSUE: GRAPHICAL ABSTRACTS
EDITORIAL
The need for improved transition and services for adolescent and young adult patients with allergy and asthma in all settings
- Pages: 2731-2733
- First Published: 02 June 2020
GUIDELINES
EAACI Guidelines on the effective transition of adolescents and young adults with allergy and asthma
- Pages: 2734-2752
- First Published: 19 June 2020
EAACI POSITION PAPERS
Gender and occupational allergy: Report from the task force of the EAACI Environmental and Occupational Allergy Interest Group
- Pages: 2753-2763
- First Published: 12 April 2020
Considerations on biologicals for patients with allergic disease in times of the COVID-19 pandemic: An EAACI statement
- Pages: 2764-2774
- First Published: 05 June 2020
Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19: An EAACI Position Paper
- Pages: 2775-2793
- First Published: 08 June 2020
REVIEW ARTICLES
Role of IL-25, IL-33, and TSLP in triggering united airway diseases toward type 2 inflammation
- Pages: 2794-2804
- First Published: 01 August 2020
Silica-related diseases in the modern world
- Pages: 2805-2817
- First Published: 27 January 2020
Mast cells and complement system: Ancient interactions between components of innate immunity
- Pages: 2818-2828
- First Published: 23 May 2020
ORIGINAL ARTICLES
Basic and Translational Allergy Immunology
Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors
- Pages: 2829-2845
- First Published: 04 June 2020

ACE2 and TMPRSS2 expression is unique for the epithelial barrier sites, whereas CD147, cyclophilins, and CD26 are expressed in both, epithelial and immune cells. Age is a factor associated with the differential expression profiles of ACE2-, CD147- and CD26-related genes in the PBMCs and naive CD4+ T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender generally lead to the higher expression of ACE2- and CD147-related genes in the bronchial biopsy, BAL or blood.
Abbreviations: ACE2, angiotensin-converting enzyme 2; AD, atopic dermatitis; BAL, bronchoalveolar lavage; COPD, chronic obstructive pulmonary disease; CypA, cyclophilin A; CypB, cyclophilin B; GLUT1, glucose transporter 1; ILC, innate lymphoid cell; MCTs, monocarboxylate transporters; NF-ATs, nuclear factor of activated T cells; PBMCs, peripheral blood mononuclear cells; SARS-CoV-2; severe acute respiratory syndrome coronavirus 2; SLC6A19, sodium-dependent neutral amino acid transporter B(0)AT1; S100A9, protein S100-A9; TMPRSS2, transmembrane protease serine.
ORIGINAL ARTICLE
Asthma and Lower Airway Disease
Integration of metagenomics-metabolomics reveals specific signatures and functions of airway microbiota in mite-sensitized childhood asthma
- Pages: 2846-2857
- First Published: 07 June 2020

This study demonstrates shotgun sequencing of airway microbiome and untargeted metabolomics profiling of serum samples in children with mite-sensitized asthma and non-asthmatic controls. Integrative analysis identifies specific airway dysbiosis at the species level and its associated functional shift in strong associations with circulating metabolites and IgE responses to mites. Overall, dual-omics integration reveals microbe-metabolite connections perturbed in mite-sensitized pediatric asthma.
Abbreviations: KEGG, Kyoto Encyclopedia of Genes and Genomes; AUC, area under the receiver operating characteristic curve
ORIGINAL ARTICLES
Asthma and Lower Airway Disease
Metabolic shift favoring C18:0 ceramide accumulation in obese asthma
- Pages: 2858-2866
- First Published: 16 May 2020

This study evaluates the association between sphingolipid metabolism and development of obese-related asthma phenotype. Serum C18:0 ceramide is increased in patients with obese asthma. Gene expression involved in macrophage polarization may be associated with ceramide accumulation. Abbreviations: CERK, ceramide kinase; CERS6, ceramide synthase 6; PPAP2A, phosphatidic acid phosphatase type 2A; PPAP2B, phosphatidic acid phosphatase type 2B; SGMS2, sphingomyelin synthase 2; UGCG, UDP-glucose ceramide glucosyltransferase.
Rhinitis, Sinusitis, and Upper Airway Disease
Real-life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA
- Pages: 2867-2878
- First Published: 18 May 2020

This study reports on the cross-sectional evaluation of patient-reported outcome measures in 626 chronic rhinosinusitis patients of which half reported nasal polyp disease. Over 40% of patients were uncontrolled, which clearly impacted their quality of life. Sinus surgery improved patient-reported outcomes, but not in patients with a history of more than 3 procedures. Abbreviations: CRSw/sNP, chronic rhinosinusitis with/without nasal polyps; FESS, functional endoscopic sinus surgery; VAS, visual analogue scale.
Atopic Dermatitis, Urticaria and Skin Disease
Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks
- Pages: 2879-2887
- First Published: 26 May 2020

During days 0-69, lanadelumab-treated patients had a significantly lower mean monthly hereditary angioedema (HAE) attack rate vs placebo and were more likely to be responders and attack free. Protection starts early and is sustained; during steady state, lanadelumab efficacy was similar or improved vs days 0-69. Prophylactic agents with rapid onset, sustained effect, and convenient dosing frequency can improve HAE management plans. Abbreviations: HAE, hereditary angioedema; q2wks, every 2 weeks.
ORIGINAL ARTICLE
Atopic Dermatitis, Urticaria and Skin Disease
Skin pH–dependent Staphylococcus aureus abundance as predictor for increasing atopic dermatitis severity
- Pages: 2888-2898
- First Published: 20 June 2020

In healthy individuals, skin microbiome is stable over 8 weeks, but not in atopic dermatitis patients who show a significant increase in Staphylococcus aureus over time. Skin pH of 5.7-6.2 allows the growth of S aureus in atopic dermatitis individuals. Higher S aureus abundance at baseline is a predictor for increased S aureus and AD severity at endpoint. Abbreviations: AD, atopic dermatitis; HE, healthy.
ORIGINAL ARTICLES
Food Allergy and Gastrointestinal Disease
APPEAL-1: A multiple-country European survey assessing the psychosocial impact of peanut allergy
- Pages: 2899-2908
- First Published: 13 May 2020

The APPEAL-1 study—multidimensional, pan-European investigation of the impact of living with PA—revealed that PA imposes an adverse psychosocial impact on patients and caregivers. Study findings deepen our knowledge and understanding of the impact of PA on everyday lives. The study also underscores unmet needs and provides signposts for clinicians and policymakers on how these may be addressed. Abbreviation: PA, peanut allergy.
Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin
- Pages: 2909-2919
- First Published: 21 May 2020

Allergenic tropomyosins have dissimilar structural stabilities despite having high amino acid sequence similarity. Tropomyosins are differentially degraded in the endolysosomal compartment of antigen-presenting cells due to differences in their structural stability. Tropomyosin T-cell cross-reactivity, unlike IgE antibody cross-reactivity, is dependent on structural stability rather than amino acid sequence similarity.
APPEAL-1: A pan-European survey of patient/caregiver perceptions of peanut allergy management
- Pages: 2920-2935
- First Published: 21 May 2020

The APPEAL-1 study – pan-European quantitative investigation of the burdenof living with peanut allergy – provides essential insight on diagnosis and management of peanut allergy. Study results expand our understanding of management of peanut allergy and provide insight into diagnosis, comorbidities, and severity of symptoms. The study suggests a widespread need for improved quality of peanut allergy health management and education. Abbreviations: AAI, adrenaline auto-injector; HCP, healthcare professional; OFC, oral food challenge; PA, peanut allergy; SPT, skin prick test.
LETTERS TO THE EDITOR
Unraveling the complexity of atopic dermatitis: The CK-CARE approach toward precision medicine
- Pages: 2936-2938
- First Published: 22 January 2020
Epinephrine drives human M2a allergic macrophages to a regulatory phenotype reducing mast cell degranulation in vitro
- Pages: 2939-2942
- First Published: 04 April 2020
Rapid drug desensitization for platinum-based chemotherapy drugs significantly increases peripheral blood IL-10 levels
- Pages: 2942-2945
- First Published: 11 April 2020
Association between keratoconus and the risk of adolescent- or adult-onset atopic dermatitis
- Pages: 2946-2948
- First Published: 14 April 2020
Efficacy of oral ondansetron in acute FPIES: A case series of 6 patients
- Pages: 2949-2951
- First Published: 23 April 2020
A highly sensitive bioluminescent method for measuring allergen-specific IgE in microliter samples
- Pages: 2952-2956
- First Published: 14 May 2020
ADHD in school-age children is related to infant exposure to systemic H1-antihistamines
- Pages: 2956-2957
- First Published: 22 May 2020
Validation of the MASK-air app for assessment of allergic rhinitis
- Pages: 2958-2961
- First Published: 25 May 2020
Acute systemic reactions to sublingual immunotherapy for house dust mite
- Pages: 2962-2963
- First Published: 25 May 2020
Validation of the ARIA items to assess allergic rhinitis control (ARIA-C)
- Pages: 2964-2966
- First Published: 25 May 2020
Association of phthalates with nasal patency and small airway dysfunction in first-grade elementary school children
- Pages: 2967-2969
- First Published: 30 May 2020
T cell requirement and phenotype stability of house dust mite–induced neutrophil airway inflammation in mice
- Pages: 2970-2973
- First Published: 01 June 2020
Successful oral desensitization and reintroduction in selected glioma patients with procarbazine-mediated hypersensitivity
- Pages: 2974-2976
- First Published: 02 June 2020
For hazelnut allergy, component testing of Cor a 9 and Cor a 14 is relevant also in birch-endemic areas
- Pages: 2977-2980
- First Published: 04 June 2020
Is self-reported history of eczema and hay fever a valid measure of atopy in those who report current asthma?
- Pages: 2981-2984
- First Published: 08 June 2020
Serum cytokine concentrations and asthma persistence to middle age
- Pages: 2985-2988
- First Published: 14 June 2020
A myoferlin gain-of-function variant associates with a new type of hereditary angioedema
- Pages: 2989-2992
- First Published: 16 June 2020
Direct and indirect costs of allergic and non-allergic rhinitis in the Netherlands
- Pages: 2993-2996
- First Published: 16 June 2020
Is time to remove parabens from standard patch test batteries? Retrospective study of 10 461 patients
- Pages: 2997-2999
- First Published: 19 June 2020
NEWS & VIEWS: Legends of Allergy and Immunology
Legends of Allergy and Immunology
Andrew Szczeklik: From fine art, music and literature to front science
- Pages: 3000-3002
- First Published: 14 March 2020
News & Views: Algorithms in Allergy and Clinical Immunology
Algorithms in Allergy and Clinical Immunology
Medical algorithm: Diagnosis and treatment of hypereosinophilic syndrome
- Pages: 3003-3006
- First Published: 16 May 2020
News & Views: Groundbreaking Discoveries in Immunology
Groundbreaking Discoveries in Immunology
Biologics as a therapeutic approach for a Th17-mediated severe dermatitis in skin barrier disorders
- Pages: 3007-3008
- First Published: 24 June 2020
CORRESPONDENCE
Silica-related diseases in the modern world: A role for self-DNA sensing in lung inflammatory diseases
- Pages: 3009-3010
- First Published: 06 November 2020
Reply to correspondence: Silica-related diseases in the modern world: A role for self-DNA sensing in lung inflammatory
- Pages: 3011
- First Published: 06 November 2020