• Issue

    Allergy: Volume 75, Issue 11

    2721-3011
    November 2020

ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 2721
  • First Published: 06 November 2020

ISSUE INFORMATION - TOC

Free Access

Issue Information

  • Pages: 2725-2726
  • First Published: 06 November 2020

IN THIS ISSUE: GRAPHICAL ABSTRACTS

In This Issue: Graphical Abstracts

  • Pages: 2727-2730
  • First Published: 06 November 2020

EAACI POSITION PAPERS

ORIGINAL ARTICLES

Basic and Translational Allergy Immunology

Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors

  • Pages: 2829-2845
  • First Published: 04 June 2020
Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors

ACE2 and TMPRSS2 expression is unique for the epithelial barrier sites, whereas CD147, cyclophilins, and CD26 are expressed in both, epithelial and immune cells. Age is a factor associated with the differential expression profiles of ACE2-, CD147- and CD26-related genes in the PBMCs and naive CD4+ T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender generally lead to the higher expression of ACE2- and CD147-related genes in the bronchial biopsy, BAL or blood.

Abbreviations: ACE2, angiotensin-converting enzyme 2; AD, atopic dermatitis; BAL, bronchoalveolar lavage; COPD, chronic obstructive pulmonary disease; CypA, cyclophilin A; CypB, cyclophilin B; GLUT1, glucose transporter 1; ILC, innate lymphoid cell; MCTs, monocarboxylate transporters; NF-ATs, nuclear factor of activated T cells; PBMCs, peripheral blood mononuclear cells; SARS-CoV-2; severe acute respiratory syndrome coronavirus 2; SLC6A19, sodium-dependent neutral amino acid transporter B(0)AT1; S100A9, protein S100-A9; TMPRSS2, transmembrane protease serine.

ORIGINAL ARTICLE

Asthma and Lower Airway Disease

Integration of metagenomics-metabolomics reveals specific signatures and functions of airway microbiota in mite-sensitized childhood asthma

  • Pages: 2846-2857
  • First Published: 07 June 2020
Integration of metagenomics-metabolomics reveals specific signatures and functions of airway microbiota in mite-sensitized childhood asthma

This study demonstrates shotgun sequencing of airway microbiome and untargeted metabolomics profiling of serum samples in children with mite-sensitized asthma and non-asthmatic controls. Integrative analysis identifies specific airway dysbiosis at the species level and its associated functional shift in strong associations with circulating metabolites and IgE responses to mites. Overall, dual-omics integration reveals microbe-metabolite connections perturbed in mite-sensitized pediatric asthma.

Abbreviations: KEGG, Kyoto Encyclopedia of Genes and Genomes; AUC, area under the receiver operating characteristic curve

ORIGINAL ARTICLES

Asthma and Lower Airway Disease

Metabolic shift favoring C18:0 ceramide accumulation in obese asthma

  • Pages: 2858-2866
  • First Published: 16 May 2020
Metabolic shift favoring C18:0 ceramide accumulation in obese asthma

This study evaluates the association between sphingolipid metabolism and development of obese-related asthma phenotype. Serum C18:0 ceramide is increased in patients with obese asthma. Gene expression involved in macrophage polarization may be associated with ceramide accumulation. Abbreviations: CERK, ceramide kinase; CERS6, ceramide synthase 6; PPAP2A, phosphatidic acid phosphatase type 2A; PPAP2B, phosphatidic acid phosphatase type 2B; SGMS2, sphingomyelin synthase 2; UGCG, UDP-glucose ceramide glucosyltransferase.

Rhinitis, Sinusitis, and Upper Airway Disease

Open Access

Real-life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA

  • Pages: 2867-2878
  • First Published: 18 May 2020
Real-life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA

This study reports on the cross-sectional evaluation of patient-reported outcome measures in 626 chronic rhinosinusitis patients of which half reported nasal polyp disease. Over 40% of patients were uncontrolled, which clearly impacted their quality of life. Sinus surgery improved patient-reported outcomes, but not in patients with a history of more than 3 procedures. Abbreviations: CRSw/sNP, chronic rhinosinusitis with/without nasal polyps; FESS, functional endoscopic sinus surgery; VAS, visual analogue scale.

Atopic Dermatitis, Urticaria and Skin Disease

Open Access

Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks

  • Pages: 2879-2887
  • First Published: 26 May 2020
Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks

During days 0-69, lanadelumab-treated patients had a significantly lower mean monthly hereditary angioedema (HAE) attack rate vs placebo and were more likely to be responders and attack free. Protection starts early and is sustained; during steady state, lanadelumab efficacy was similar or improved vs days 0-69. Prophylactic agents with rapid onset, sustained effect, and convenient dosing frequency can improve HAE management plans. Abbreviations: HAE, hereditary angioedema; q2wks, every 2 weeks.

ORIGINAL ARTICLE

Atopic Dermatitis, Urticaria and Skin Disease

Open Access

Skin pH–dependent Staphylococcus aureus abundance as predictor for increasing atopic dermatitis severity

  • Pages: 2888-2898
  • First Published: 20 June 2020
Skin pH–dependent Staphylococcus aureus abundance as predictor for increasing atopic dermatitis severity

In healthy individuals, skin microbiome is stable over 8 weeks, but not in atopic dermatitis patients who show a significant increase in Staphylococcus aureus over time. Skin pH of 5.7-6.2 allows the growth of S aureus in atopic dermatitis individuals. Higher S aureus abundance at baseline is a predictor for increased S aureus and AD severity at endpoint. Abbreviations: AD, atopic dermatitis; HE, healthy.

ORIGINAL ARTICLES

Food Allergy and Gastrointestinal Disease

Open Access

APPEAL-1: A multiple-country European survey assessing the psychosocial impact of peanut allergy

  • Pages: 2899-2908
  • First Published: 13 May 2020
APPEAL-1: A multiple-country European survey assessing the psychosocial impact of peanut allergy

The APPEAL-1 study—multidimensional, pan-European investigation of the impact of living with PA—revealed that PA imposes an adverse psychosocial impact on patients and caregivers. Study findings deepen our knowledge and understanding of the impact of PA on everyday lives. The study also underscores unmet needs and provides signposts for clinicians and policymakers on how these may be addressed. Abbreviation: PA, peanut allergy.

Open Access

Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin

  • Pages: 2909-2919
  • First Published: 21 May 2020
Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin

Allergenic tropomyosins have dissimilar structural stabilities despite having high amino acid sequence similarity. Tropomyosins are differentially degraded in the endolysosomal compartment of antigen-presenting cells due to differences in their structural stability. Tropomyosin T-cell cross-reactivity, unlike IgE antibody cross-reactivity, is dependent on structural stability rather than amino acid sequence similarity.

Open Access

APPEAL-1: A pan-European survey of patient/caregiver perceptions of peanut allergy management

  • Pages: 2920-2935
  • First Published: 21 May 2020
APPEAL-1: A pan-European survey of patient/caregiver perceptions of peanut allergy management

The APPEAL-1 study – pan-European quantitative investigation of the burdenof living with peanut allergy – provides essential insight on diagnosis and management of peanut allergy. Study results expand our understanding of management of peanut allergy and provide insight into diagnosis, comorbidities, and severity of symptoms. The study suggests a widespread need for improved quality of peanut allergy health management and education. Abbreviations: AAI, adrenaline auto-injector; HCP, healthcare professional; OFC, oral food challenge; PA, peanut allergy; SPT, skin prick test.

LETTERS TO THE EDITOR

NEWS & VIEWS: Legends of Allergy and Immunology

Legends of Allergy and Immunology

News & Views: Algorithms in Allergy and Clinical Immunology

Algorithms in Allergy and Clinical Immunology

News & Views: Groundbreaking Discoveries in Immunology