• Issue
    Volume 25, Issue 5
    October 2023

ISSUE INFORMATION

Free Access

Issue Information

  • First Published: 18 October 2023

EDITORIALS

ORIGINAL ARTICLES

Evaluating antimicrobial duration for Gram-negative bacteremia in patients with neutropenia due to hematologic malignancy or hematopoietic stem cell transplantation

  • First Published: 06 June 2023

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In the management of immunocompromised patients with neutropenia and Gram-negative bloodstream infection, short antimicrobial courses (≤10 days) had comparable propensity score-adjusted 90-day outcomes as intermediate (11–14 days) or prolonged regimens (≥15 days).

Open Access

Perfusion fluid-related infections in liver transplant recipients: A 5-year, single-center, retrospective study

  • First Published: 21 August 2023
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Perfusion fluid-related infections in liver transplant recipients: a 5-year, single center, retrospective study. Perfusion fluid-related infections were associated with longer ICU stays and higher 1-year mortality, both overall and related to infection.

Gut microbiota trajectory in β-thalassemia major children who underwent allogeneic hematopoietic stem cell transplantation

  • First Published: 24 August 2023
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This study aimed to evaluate microbiota composition pre-HSCT and post-HSCT in children with β-thalassemia major. The gut microbiota of the 22 β-TM children showed a clear trend of destruction and reconstruction within 100 days after HSCT. Decreased Bacteroidetes levels may be associated with GVHD onset.

Clinical and immune features of human parvovirus B19 infection in allogeneic stem cell transplantation recipients: A retrospective monocentric study

  • First Published: 18 August 2023

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Thirty-five cases of B19V PCR positivity were retrospectively reported in our center on 11 years-period. Infection presentations were heterogeneous, but hematological impairment was often at the forefront.

Open Access

Does therapeutic drug monitoring (TDM) of trough concentrations suffice for optimizing preemptive therapy with ganciclovir of cytomegalovirus infections in non-renal solid organ transplant recipients?

  • First Published: 29 July 2023
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No clear relationship between ganciclovir/valganciclovir exposure and cytomegalovirus eradication or safety issues (myelotoxicity, hepatotoxicity, and neurotoxicity) was reported in 29 liver-, heart-, and lung-transplant recipients treated with preemptive therapy according to a real-time therapeutic drug monitoring-guided expert clinical pharmacological advice approach.

Safety and efficacy of weight-based ganciclovir dosing strategies in overweight/obese patients

  • First Published: 24 August 2023
Description unavailable

In this study of overweight/obese patients with CMV, adjusted body weight dosing of ganciclovir was not associated with decreased rates of neutropenia or treatment efficacy as compared to total body weight dosing.

Cytomegalovirus Immune reconstitution in cord blood transplant recipients on letermovir prophylaxis

  • First Published: 12 July 2023

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Although approximately half of the cytomegalovirus (CMV)-seropositive cord blood transplant recipients reconstituted their CMV-specific cell-mediated immunity during letermovir prophylaxis, the immune responses were not sufficiently robust to protect them against clinically significant reactivations.

Open Access

Safety and efficacy of one and two booster doses of SARS-CoV-2 mRNA vaccines in kidney transplant recipients: A randomized clinical trial

  • First Published: 19 September 2023

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Sequential administration of two booster doses of SARS-CoV-2 mRNA vaccine is safe and significantly increases seroconversion rate (SARS-CoV-2 IgG ≥10 AU/ml) compared to one booster dose in kidney transplant recipients who remained without a positive humoral response after the previous two-dose vaccination schedule.

BRIEF COMMUNICATIONS

When you need to dive in the deep end—Transplanting SARS-CoV-2 PCR+ recipients

  • First Published: 01 August 2023

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Organ transplantation can proceed in select minimally symptomatic non-lung transplant recipients with positive SARS-CoV-2 PCR at time of transplantation.

Outcomes of transplant recipients with pretransplant Nocardia colonization or infection

  • First Published: 28 June 2023
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Among nine patients with pretransplant Nocardia colonization or infection, no one developed nocardiosis after solid organ or allogeneic stem cell transplantation. Nocardiosis should not necessarily preclude transplantation provided there is an adequate clinical and radiographic response to treatment.

Previous use of statins does not improve the outcome of bloodstream infection after kidney transplantation

  • First Published: 21 August 2023
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In this single-center study, previous statin therapy had no apparent protective effect on the outcome of posttransplant bloodstream infection among kidney transplant recipients.