Almost all countries demonstrated increasing male ASDRs over the observation period. There was greater heterogeneity between countries regarding female ASDRs. The most recent Joinpoint analysis 2016–2019 shows significantly decreasing mortality in all countries except the United Kingdom. Incidence rates increased in all countries, with evidence of plateau from 2015 onwards.

The incidence of desmoplastic melanoma (DM) in Sweden remains stable, unlike rising cutaneous melanoma rates. Despite advanced tumour features, DM patients have better survival outcomes. However, recent survival improvements are lacking, potentially due to limited treatment options compared to other melanoma subtypes.

In this randomized trial on the impact of modification of light dose and fluence rate in ALA-PDT for actinic keratoses, we found that halving the light dose and/or fluence rate did not negatively affect the therapeutic outcome. In addition, halving the fluence rate significantly decreased cPDT-induced pain during illumination.

HS treatment algorithm.

The combination of high-resolution imaging (LC-OCT) and artificial intelligence (AI) represents a promising tool for better understanding wound healing, evaluating the efficacy of current wound care interventions and analysing keratinocyte behaviour in detail during the wound healing process.

In the study, the authors have identified dermoscopic patterns that are associated with different stages in the life cycle of nevi. New nevi were associated with peripheral globules and smudgy patterns. Growing nevi were associated with peripheral globules and negative network patterns. Stable nevi were associated with reticular, structureless and central globules with peripheral network patterns.

The European Reference Network for Rare Skin Diseases has developed consensus-based oral health care pathways for dental referral, treatment and follow-up for patients with EB according to their risk for oral and dental manifestations and complications. Referral for early preventive strategies is key to reducing the burden of disease.

Follow-up data 6 and 12 months after field-directed photodynamic therapy (PDT) for treatment of actinic keratosis (AK) in a phase III study. Sustained participant complete clearance. Participants who showed clinical complete clearance of AK lesions 12 weeks after PDT were assessed for recurrences. The sustained complete clearance was higher for BF-200 ALA than for placebo throughout the follow-up. Reduction in skin quality impairment. All parameters of skin quality improved during follow-up.

Epidemiology, associated comorbidities and current treatment patterns of Adamantiades–Behçet's disease in Germany.

This graphical abstract illustrates the impact of dermoscopic image quality on the performance of clinicians and a CNN model. It presents examples from the 303-image test set and compares the CNN's AUROC across different image qualities against clinician performance.

Effect of patient-contextual dermoscopy sets (right panel) was assessed. Participants classified (melanoma versus benign) the index lesion (blue border) before and after the remaining set was presented. Specificity decreased without significant change in sensitivity. 27.8% of human-readers outperformed the winning AI algorithm (AUROC = 0.930) from an online competition in enhanced-contextual assessment.

This scoping review gathers evidence on patient- and HCP perceptions on interdisciplinary care (IC) for Immune-mediated inflammatory Diseases with Skin manifestations (skIMID) and state-of-the-art of measurement. IC experience is captured very heterogeneously and strongly depends on the context of the care provider. Experience seems to be better in local programmes than systems rolled out in larger geographical regions. Future need is to develop a standardized core IC outcome set, including medical-, process- and financial indicators, patient and HCP care experience measures. Such data will support benchmarking and identification of improvement areas in quality of care.

The nationwide representative C³O study shows clear deficits in UV-specific skin cancer knowledge among 1200 German coaches interviewed. Significant differences were evident across different sports as well as between micro and meso-level characteristics.

The integration of dermatologist into primary care settings is cost-effective and streamlines the management of patients with skin conditions. The cost for each additional pre-malignancy or malignancy treated is €853 lower, and for any additional skin finding treated, €381 lower than that of the standard care pathway.

LC-OCT markedly increases the diagnostic accuracy in the differentiation of BCC from imitators and in the discrimination across BCC subtypes. LC-OCT criteria such as lobule content, shape and location are crucial for BCC diagnosis and subtype classification. A straightforward, user-friendly diagnostic algorithm is proposed for BCC diagnosis and subtype discrimination.

Genital herpes—guidelines for diagnostic and treatment (2024): strategies for diagnosis, management and follow-up of the most common sexually transmitted infection. The guidelines covers common clinical scenarios (including recurrent genital herpes), infection during pregnancy and coinfection with human immunodeficiency virus.

Unlike the gut, the skin appears uniform at first glance. However, histological and molecular biological research has revealed significant regional variations in the composition and function of its main barrier elements. In this review, we describe the topographical differences of four barrier elements in healthy skin: microbiome, chemical, physical and immunological barriers. We also discuss the role of these regional variations in the pathogenesis of certain inflammatory skin diseases.

Darier disease (DD) is characterized by the following: Disrupted Ca²⁺ gradients, impaired desmosomes, impaired keratinocyte differentiation, type 17 inflammation, DC and LC ↓, Th17 cells ↑. DD treatment: First line: keratinocyte focused and/or anti-inflammatory. Second line: experimental approaches like specific targeting of the inflammatory infiltrate.

We report 32 cases of infection by Trichophyton mentagrophytes ITS genotype VII, including a cluster of 17 cases, occurring in Paris, France between 2022 and 2023. Our findings confirm the circulation of the infection among men who have sex with men (MSM). The study highlights that the incubation period can be prolonged and is at risk of transmission. Topical antifungal treatments alone are often insufficient for achieving a cure, and oral treatments need to be prescribed for an extended duration. Additionally, patients remain contagious even after starting antifungal treatment.

Overall, 67 patients were included from 15 French centres (35 children and 32 adults). After the first sirolimus temporary withdrawal, mean time to recurrence of symptoms was 6.4 ± 9.6 months (survival curve). Sirolimus was overall well-tolerated (radar chart). Serious adverse events occurred in six patients (9.0%), especially respiratory infections. There were two cases of ovarian cysts. Conclusion. The real-life study SIROLO provides answers on persistence of efficacy over time, long-term side effects and time to recurrence in case of sirolimus withdrawal.

Background, key points, current state of management in dermato-oncology centres and algorithm for standardized monitoring and management of ICIPI; *routine radiographic imaging according to respective guidelines; **3 months after routine radiographic staging (6-monthly); ***if not recently performed as part of the routine staging. Abbreviations: ICI, Immune Checkpoint Inhibitor; ICIPI, Immune Checkpoint Inhibitor-Associated Pancreatic Injury; Q3M/Q6M, 3- and 6-monthly interval; Tx, treatment.

This study found that doxycycline prophylaxis offers signification reductions in common bacterial sexually transmitted infections (STIs), specifically in men who have sex with men. Both doxycycline pre- and post-exposure prophylaxis offer significant reduction in the transmission of STIs and have benign safety profiles. However, additional research is needed to determine the effects of doxycycline prophylaxis in other subpopulations as well as its effects on antimicrobial resistance.

When compared with the gold standard histopathologic examination, the non-invasive RCM imaging technique has a negative predictive value (true negative margins confirmed by histopathology among all negative margins analysed by RCM) of 89.15%, highlighting its efficacy for margin mapping of melanoma of the lentigo maligna type.

Key confocal features in LM/LMM progression: Architecture: AIMP: Preserved; LM: Non-edged papillae; LMM: Epidermal/junctional disarray, collagen fibre destruction. Cellular distribution: AIMP: Junctional scattered atypical cells; LM: Widespread pagetoid and junctional atypical cells with junctional nests; LMM: Widespread pagetoid and junctional atypical cells with junctional and dermal nests. Cell Types: AIMP: Dendritic cells with mild atypia; LM/LMM: Dendritic cells with mild atypia, round nucleated cells with marked atypia.

In FRONTIER-2 (NCT04212169), a Phase 2a, randomized, placebo-controlled study of 148 adults with moderate-to-severe atopic dermatitis, no statistically significant differences between tozorakimab and placebo were observed in the percentage change in EASI score from baseline to Week 16. The proportion of EASI-75 and IGA 0/1 responders at Week 16 was numerically higher in the tozorakimab 600 mg group than in the placebo group. Serum pharmacokinetics were dose-dependent, immunogenicity incidence was low and tozorakimab was well tolerated.

Delphi Consensus on EGFRi-induced acneiform rash: management guidelines on early diagnosis and grading, prophylactic and pre-emptive treatment, reactive and personalized patient care.

Utilizing the Icelandic Cancer Registry, this whole-population study found a surge in invasive and in situ melanoma incidence in the early 2000s. This surge was primarily observed in urban populations, with females consistently exhibiting higher incidence than males. Though incidence has decreased since the early 2000s, in situ melanomas are again on the rise in recent years in males and females, as well as invasive melanoma in rural females.

In this systematic review and network meta-analysis of Janus kinase (JAK) inhibitors for alopecia areata (AA), no evidence of a difference between ritlecitinib 50 mg and baricitinib 4 mg on Severity of Alopecia Tool (SALT) ≤10 (odds ratio,OR: 0.96, 95% credible interval,CrI: 0.18–7.21) and SALT ≤20 (OR: 1.19, 95% CrI: 0.23–10.67) at Week 24 was found. Using individual patient data from the ALLEGRO trial (NCT03732807), evidence of effect modification by sex, SALT score at baseline, duration of current episode and disease duration was found, although the results were unchanged due to a small number of included trials. Further research on novel treatment for AA is warranted.