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    Issue
    Volume 12, Issue 2
    177-332
    April 2013
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Original Articles

Open Access

Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene

Elena Beltrami, Antonella Ruggiero, Rita Busuttil, Enrica Migliaccio, Pier Giuseppe Pelicci, Jan Vijg, Marco Giorgio,
  • Pages: 177-183
  • First Published: 12 December 2012
Open Access

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

Marian Beekman, Hélène Blanché, Markus Perola, Anti Hervonen, Vladyslav Bezrukov, Ewa Sikora, Friederike Flachsbart, Lene Christiansen, Anton J. M. De Craen, Tom B. L. Kirkwood, Irene Maeve Rea, Michel Poulain, Jean-Marie Robine, Silvana Valensin, Maria Antonietta Stazi, Giuseppe Passarino, Luca Deiana, Efstathios S. Gonos, Lavinia Paternoster, Thorkild I. A. Sørensen, Qihua Tan, Quinta Helmer, Erik B. van den Akker, Joris Deelen, Francesca Martella, Heather J. Cordell, Kristin L. Ayers, James W. Vaupel, Outi Törnwall, Thomas E. Johnson, Stefan Schreiber, Mark Lathrop, Axel Skytthe, Rudi G. J. Westendorp, Kaare Christensen, Jutta Gampe, Almut Nebel, Jeanine J. Houwing-Duistermaat, Pieternella Eline Slagboom, Claudio Franceschi, the GEHA consortium ,
  • Pages: 184-193
  • First Published: 03 January 2013
Open Access

Gene expression profile of mouse white adipose tissue during inflammatory stress: age-dependent upregulation of major procoagulant factors

Marlene E. Starr, Yanling Hu, Arnold J. Stromberg, Joseph R. Carmical, Thomas G. Wood, B. Mark Evers, Hiroshi Saito,
  • Pages: 194-206
  • First Published: 27 December 2012
Open Access

Ambulant 24-h glucose rhythms mark calendar and biological age in apparently healthy individuals

Carolien A. Wijsman, Diana van Heemst, Evelien S. Hoogeveen, P. Eline Slagboom, Andrea B. Maier, Anton J. M. de Craen, Frans van der Ouderaa, Hanno Pijl, Rudi G. J. Westendorp, Simon P. Mooijaart,
  • Pages: 207-213
  • First Published: 26 December 2012
Open Access

Quantification of in vivo oxidative damage in Caenorhabditis elegans during aging by endogenous F3-isoprostane measurement

Christiaan F. Labuschagne, Edwin C. A. Stigter, Margriet M. W. B. Hendriks, Ruud Berger, Joshua Rokach, Hendrik C. Korswagen, Arjan B. Brenkman,
  • Pages: 214-223
  • First Published: 27 December 2012
Open Access

Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain

Cheryl A. Hawkes, Maureen Gatherer, Matthew M. Sharp, Adrienne Dorr, Ho Ming Yuen, Rajesh Kalaria, Roy O. Weller, Roxana O. Carare,
  • Pages: 224-236
  • First Published: 18 February 2013
Open Access

The role of lipid-related genes, aging-related processes, and environment in healthspan

Alexander M. Kulminski, Irina Culminskaya, Konstantin G. Arbeev, Svetlana V. Ukraintseva, Eric Stallard, Liubov Arbeeva, Anatoli I. Yashin,
  • Pages: 237-246
  • First Published: 16 January 2013
Open Access

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

Marco De Cecco, Steven W. Criscione, Edward J. Peckham, Sara Hillenmeyer, Eliza A. Hamm, Jayameenakshi Manivannan, Abigail L. Peterson, Jill A. Kreiling, Nicola Neretti, John M. Sedivy,
  • Pages: 247-256
  • First Published: 30 January 2013
Open Access

Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model

Edoardo Parrella, Tom Maxim, Francesca Maialetti, Lu Zhang, Junxiang Wan, Min Wei, Pinchas Cohen, Luigi Fontana, Valter D. Longo,
  • Pages: 257-268
  • First Published: 30 January 2013
Open Access

Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon crypts

John C. F. Hsieh, David Van Den Berg, Haeyoun Kang, Chih-Lin Hsieh, Michael R. Lieber,
  • Pages: 269-279
  • First Published: 20 February 2013
Open Access

Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells

Wen Guo, Eric Bachman, Michelle Li, Cindy N. Roy, Jerzy Blusztajn, Siu Wong, Stephen Y. Chan, Carlo Serra, Ravi Jasuja, Thomas G. Travison, Martina U. Muckenthaler, Elizabeta Nemeth, Shalender Bhasin,
  • Pages: 280-291
  • First Published: 08 February 2013
Open Access

Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease

Elena Alberdi, Ane Wyssenbach, María Alberdi, Mª V. Sánchez-Gómez, Fabio Cavaliere, José J. Rodríguez, Alexei Verkhratsky, Carlos Matute,
  • Pages: 292-302
  • First Published: 15 February 2013
Open Access

In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors

Michelle Ratliff, Sarah Alter, Daniela Frasca, Bonnie B. Blomberg, Richard L. Riley,
  • Pages: 303-311
  • First Published: 15 February 2013

Short Takes

Open Access

Cytogenetic analysis of human cells reveals specific patterns of DNA damage in replicative and oncogene-induced senescence

Germana Falcone, Alessia Mazzola, Flavia Michelini, Gianluca Bossi, Federica Censi, Maria G. Biferi, Luisa Minghetti, Giovanna Floridia, Maurizio Federico, Antonio Musio, Marco Crescenzi,
  • Pages: 312-315
  • First Published: 21 November 2012
Open Access

Defective ATM-Kap-1-mediated chromatin remodeling impairs DNA repair and accelerates senescence in progeria mouse model

Baohua Liu, Zimei Wang, Shrestha Ghosh, Zhongjun Zhou,
  • Pages: 316-318
  • First Published: 23 November 2012
Open Access

The gastrointestinal manifestations of telomere-mediated disease

Naudia L. Jonassaint, Nini Guo, Joseph A. Califano, Elizabeth A. Montgomery, Mary Armanios,
  • Pages: 319-323
  • First Published: 28 December 2012
Open Access

Towards a gene expression biomarker set for human biological age

Alice C. Holly, David Melzer, Luke C. Pilling, William Henley, Dena G. Hernandez, Andrew B. Singleton, Stefania Bandinelli, Jack M. Guralnik, Luigi Ferrucci, Lorna W. Harries,
  • Pages: 324-326
  • First Published: 12 January 2013
Open Access

Autophagy mediates caloric restriction-induced lifespan extension in Arabidopsis

Elena A. Minina, Victoria Sanchez-Vera, Panagiotis N. Moschou, Maria F. Suarez, Eva Sundberg, Martin Weih, Peter V. Bozhkov,
  • Pages: 327-329
  • First Published: 17 January 2013
Open Access

Telomere length behaves as biomarker of somatic redundancy rather than biological age

Jelle J. Boonekamp, Mirre J. P. Simons, Lia Hemerik, Simon Verhulst,
  • Pages: 330-332
  • First Published: 24 January 2013