The chemical nature of sodium sulfate groups in glycosylation reactions was studied. The findings enabled us to develop alternative synthesis routes for sulfated oligosaccharides. Experiments and calculations suggested that the sodium cation acts as a protecting group in glycosylation reactions.

Graphitic carbon nitride (g-C₃N₄) is functionalized with organosilver probe molecules through a Surface OrganoMetallic Chemistry (SOMC) approach. In-depth characterization using high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM), X-ray absorption (XAS), and solid-state NMR (ssNMR) spectroscopy reveal the dynamic processes during metal grafting to generate three distinct surface sites: bis-NHC-Ag⁺, dispersed Ag⁺ sites, and physisorbed molecular precursor.

A prediction model for donor number (DN) was developed using machine-learning techniques, while the electron-donating ability of polymer segments to regulate the Li⁺ solvation structure was revealed and verified. Furthermore, a high-DN zwitterionic polymer electrolyte was designed to facilitate rapid Li⁺ transportation and ensure stable long-term high-voltage cyclability in lithium-ion batteries.

A universal core saccharide was prepared on a hundred-milligram scale by glycosyltransferases and amino protecting group (APG) conversions. This core saccharide was further extended into branched precursors with specific APGs, enabling controlled glycosylations, which allowed the facile synthesis of diversified branched human milk oligosaccharides (HMOs). Glycan microarray analysis showed that these HMOs, featuring a type 1 glycan, specifically bound to certain lectins.

FasV-catalyzed multiple halogenations in naphthacemycin biosynthesis were elucidated, which led to the discovery of previously unrecognized amino acid residues critical for controlling regioselectivity and substrate specificity. These findings suggest a novel dual-activation mechanism and demonstrate its biocatalytic potential for a broader range of phenolic hydroxy-containing substrates with diverse structural frameworks.

The first inverse sandwich complexes [{(Me₃Si)₂NC(NⁱPr)₂}₂RE]₂(μ-η⁶ : η⁶-C₆H₆) with RE = trivalent yttrium, dysprosium, and erbium, are presented, which exhibit a completely planar antiaromatic benzene bridging dianion ligand. The remarkable planarity of the bridging parent benzene dianion is otherwise unknown with any s-, p-, d-, or 4f- metal, and rationalized by the match of the metals d-manifold with the π*-molecular orbital of the bridging benzene unit and strong electrostatically compression through coordination with the two cationic RE^III sites.

Fallon, Shende, Moore, and co-workers have identified for the first time genes encoding giant type I polyketide synthases (PKZILLA-1 & 2) in the “golden alga” Prymnesium parvum for the biosynthesis of the polyether toxin prymnesin-1, corroborating long-held biosynthetic postulates. The authors’ approach may serve as a blueprint for the future discovery of the biosynthetic machineries underlying other polyether toxins.

A copper-catalyzed enantioselective and 1,4-selective hydropyridylation has been developed. Using 2-fluoropyridine as the electrophile and a copper catalyst in conjunction with (R)-Tol-BINAP, the desired chiral 1,1-diaryl product was synthesized via a concerted nucleophilic aromatic substitution mechanism.

The targeted photoactivation of periodate provides a novel and operationally straightforward method for accessing oxenoid-type reactivity. Computational studies have revealed a geometric transition in periodate geometry which, when irradiated, allows for the facile extrusion of molecular oxygen. This new reaction pathway allows for the epoxidation of a broad range of olefin substrates using an organic-soluble source of periodate and violet light irradiation.

Aggregation of electroactive organic molecules in solution yields a linear relationship between the potential shift and the aggregation number, yielding a substantial voltage loss at a high concentration in an organic redox flow battery. Molecular anti-aggregation strategy is applied and the sensitivity between the voltage and the concentration is lowered.

Cross-[4+4] cycloaddition reactions of vinylidene ortho-quinone methides (VQMs) with either ortho- or para-quinone methides yielded inherently chiral eight-membered O-heterocycles in high yields with high to excellent stereoselectivity. These products display a unique combination of inherent, axial, and central chirality.

A novel smart boron nanosensitizer (BATBN) is comprised of ultrasmall boron quantum dots (BQDs) conjugated with cell-penetrating peptides, which facilitates its cellular uptake and deep tumor penetration. A self-condensation reaction of BATBN triggered by the tumor biomarker, leading to the formation of larger-sized nanoaggregates, presents a supramolecular strategy which enables precise and efficient boron neutron capture therapy (BCNT) for cancer treatment.

An organic laser material has been shown to be capable of simultaneously exhibiting amplified spontaneous emission and mechanofluorochromic properties under a wide range of shear and normal force conditions. Applying a localized mechanical pressure as low as 0.1 MPa inhibits the micro-laser behavior at the given spot, while a hydrostatic pressure of 1 to 2 GPa leads to a narrow emission and a pressure-dependent shift in the emission wavelength.

Bio-inspired, stimuli-responsive glucuronate-functionalized polymers selectively separate middle rare earth elements (MREEs), such as Samarium, over Holmium and Cerium, through tailored charge density and polymer length. Acidification triggers glucuronate protonation, releasing the MREEs and resolubilizing the polymer. The material's efficiency in separating MREEs from complex mixtures is showcased, offering a reusable, size-selective strategy for addressing challenges in MREE recovery.

Chemical reaction cycles applied to π-conjugated superstructures enable the formation of transient hydrogels whose electrical conductivity is encoded by the consumption of chemical fuels.

The frequent start-up and shut-down (SU/SD) caused fuel starvation operation condition seriously deteriorates the performance and lifetime of the fuel cell (HT-PEMFCs). We proposed the temperature-matched hydrogen-induced metal-insulator phase transition for controlling activity and fuel starvation tolerance in HT-PEMFCs.

A new strategy for comprehensive single-cell secretome profiling (SCSP) by integrating metabolic labeling of newly synthesized proteins, click chemistry-based enrichment in an alkyne micro-reactor, in situ digestion, and nanoLC-MS/MS analysis. SCSP enables an unprecedented depth of the secretome identification, providing a new avenue for studying secretion heterogeneity at the single-cell level.

We discovered that the non-conjugated piperazine-2,5-dione unit fully tautomerizes into the conjugated 3,6-dihydropyrazine-2,5-diol unit via a long-range vinylogous effect, driven by energy minimization through π-electron delocalization along the polymer backbone. This fully conjugated backbone enhances charge transport, while lactim units strongly interact with fluoride ions, making this polymer effective in water-gated field-effect transistor fluoride sensors.

Some difficult chemical reactions occur spontaneously in water microdroplets, and electric fields at the air–water interface are thought to be the main cause. Using theoretical computations for two prototypical processes involving OH⁻ we show that the magnitude of the electric fields required to make the processes favorable are much higher than those existing at the pristine air–water interface. We discuss the implications of the results.

Regulating the electron delocalization of Ni active sites can significantly alter the attack sites of OH⁻ ions, modulate the dissociation pattern of urea molecules, effectively optimizing the product selectivity and enhancing the reaction efficiency in urea oxidation reaction.

Hollow nanocages with Pt epitaxy grown on RuCu have been successfully synthesized as efficient electrocatalysts via a galvanic replacement strategy, exploiting the distinct electrochemical potentials of Pt, Ru, and Cu. The optimized Pt_8.7-RuCu NCs/C catalysts not only exhibite exceptional HOR performance, but achieve a significantly higher specific peak power density (15.9 W mg_Pt+Ru⁻¹) under fuel cell conditions, making them a promising high-efficiency anode nanocatalyst for practical AEMFC applications.

A series of novel multi-component copolymerized donors were successfully synthesized, and excellent efficiencies in both rigid binary (18.09 %) and ternary (19.05 %) as well as flexible binary (16.63 %) OSCs for flexible linker-sequential block MCD PM6-C1_0.8-b-D18-Cl_0.2-BTD were achieved, along with excellent long term photovoltaic stability (T₈₀=9,078 h) and photo-stability (T₈₀=568 h) in invert OSCs as well as outstanding crack-onset strain (COS) value of 49.88 % and 31.29 % in both pristine and blend films, respectively.

We present a novel 4D printing approach using digital light processing (DLP) to fabricate complex, multifunctional 3D structures from liquid crystal (LC) emulsions. This method preserves LC ordering, imparting tunable shape memory, light responsiveness, and porosity. The addition of chiral nematic LCs enables adjustable reflective properties, offering potential for applications in adaptive optics, robotics, and photonics.

A Li⁺-conducted coordination hypercrosslinked MOP (CHMOP-Li) polymer electrolyte was developed for high-energy solid-state Li batteries, which is based on a cellulose-based copolymer with metal-organic polyhedra (MOPs) as the crosslinking agent. Benefiting from the advantages of MOPs and cellulose-based copolymers, the CHMOP-Li electrolytes exhibit both high ionic conductivity of 1.02×10⁻³ S cm⁻¹ and high Li⁺ transference number of 0.75 at 25 °C. The solid-state Li−O₂ batteries fabricated with CHMOP electrolyte show good cycling performance (500 cycles) and high discharge capacity (15740 mAh g⁻¹).

Neuromorphic nanofluidic sense digitalization is devised by a nanofluidic dopaminergic nerve to manage the robot. The dopamine recognition by aptamer and the corresponding ionic signaling are more analogous to the processes in biology. Dopaminergic modulation of synaptic transmission is uncovered by many neurologic functions, and control of the robotic arm is realized by digital representation of the dopamine-dependent plasticity.

This work presents the first example of piezo-photocatalytic synthesis of hydrogen peroxide (H₂O₂) using covalent organic frameworks (COFs). Under the synergy of the intermolecular multiple-channel charge transfer and the piezoelectric polarization field, charge separation was greatly improved and ethenyl group-modified bicarbazole-based COFs (COF-DH-Eth) achieved a record-breaking H₂O₂ synthesis rate (9212 μmol g⁻¹ h⁻¹).

An integrated DNA data storage pipeline is invented to streamline the whole process from DNA chemosynthesis to pyrosequencing on the surface of magnetic beads in droplets manipulated by a homemade digital microfluidic cartridge. Overall, it takes 6.5 hours to writing and reading 8 bytes of data (49 min/byte) with up to 100 % text accuracy by plural voting and RS coding.

Cyclic fixation-release of dilute CO₂ was carried out continuously in a system consisting of a zinc complex and an electrolytic cell with bipolar membrane. CO₂ fixation is promoted by the formation of carbonate-coordinated complex, and CO₂ release is induced by decomposition of the complex structure accompanied by protonation of the ligand. Reconstruction of the complex structure by ligand deprotonation closes the cycle to enable CO₂ refixation.

The rapid capacity decay mechanism of LRLO during LDOD cycling is elucidated. The accumulation of activated Oⁿ⁻ and persistent vacancy-rich state intensified TM in-plane migration, leading to the vacancies transition from separated to aggregated states, facilitating detrimental out-of-plane TM migration. Furthermore, increased anionic redox reactions resulted in cathode-to-anode shuttle of Oⁿ⁻ and by-products, leading to lithium loss.

A hydration-mediated molecular engineering strategy has been used for the in situ generation of flexible heterojunctions that display ultralow-loss optical waveguides, high flexibility and controllable emission sequences. This integration of the benefits of flexibility and heterojunctions approach offers the possibility for developing photonic information encryption systems.

Here, we report an aniline-phenol-based rotary molecular motor that operates via an information ratchet mechanism. The 360° directional rotation about a single covalent bond can be chemically driven by reversible oxazepine formation. Both the oxazepine formation and hydrolysis steps are kinetically gated via dynamic kinetic resolution, arising from the kinetic bias of chiral catalysts for enantiomers.

Operationally convenient one-pot one-step cobalt-catalyzed and enantioselective one-pot two-step copper-catalyzed sequential hydrosilylation/hydroboration of arylidenecylcopropanes are developed to prepare racemic and enantioenriched 1,4-borylsilylalkanes with high regio- and enantioselectivity, respectively. Mechanistic studies reveal that these reactions proceed by metal-hydride-catalyzed ring-opening regioselective hydrosilylation followed by hydroboration of homoallylsilane intermediates.

The enantioselective total synthesis of kalmanol was achieved by convergent and modular synthetic strategies. Two enantioenriched fragments were assembled by a Grignard reaction/ring-closing metathesis sequence. The remaining hydroxy groups were installed by precise late-stage oxidations.

This work presents the design and synthesis of pre-organized ligands combining two lateral bis-pyridyl-phosphonated-pyclen macrocycles bridged by either a flexible linear pegylated linker (L2) or a bulkier K22 crown-ether (L3), and the regioselective formation of their dinuclear Yb complexes. Upconversion (UC) sensitization of Tb upon excitation into the Yb NIR absorption band was evaluated in D₂O, showing the heteropolynuclear complexes of L2 to be two times more intense for UC emission compared to those of L3.

A new family of volatile steroidal natural products, the batrachopolyenes, have been isolated and identified from torrent frogs. A total synthesis established their structure. These norsteroids contain a unique contracted A-ring and unusual functionalization across the structural core, which were installed along a divergent total synthetic sequence.

In this work, we comprehensively reveal the two-step “chocolate-cookie” shaped CEI formation mechanism in RT Na-S batteries driven by FEC. The solid-solid conversion of sulfur and impressive performance are achieved in this simplified system (456 mAh g⁻¹ after 1000 cycles at 0.5 C), which has the potential for further improvement.

Near-complete incorporation of trifluoromethyl methionine (tfmM) into Cyclophilin A (CypA) was achieved by cell-free synthesis, preserving its substrate binding affinity and enzymatic activity. Availability of the highly responsive and sensitive tfmM probe paves the way for studying protein-protein/ligand interactions and protein dynamics by ¹⁹F NMR spectroscopy.

Pore space partition (PSP) has been successfully achieved in two isomorphic metal–organic frameworks (MOFs) mediated by an unprecedented self-adaptive coordination evolution (SACE) on low-symmetric M₄ clusters, which provides new perspectives for MOF structural regulation and designing more advanced porous adsorbents.

Tetrahedral Mn(II) pseudohalide hybrids, (RPh₃P)₂MnBr_xNCS_4−x are introduced with R=phenyl, pentyl, or methyl, and x=1–3, synthesized by gradually substituting bromides with pseudohalides (NCS⁻). These hybrids show significant Stokes shifts and red-shifted emission (549–613 nm).

Rational design of a cost-effective coating on high-voltage NCM85 cathode for all-solid-state batteries—utilizing the stable decomposition products of LiPO₂F₂—successfully suppresses the electrochemical decomposition of the argyrodite Li₆PS₅Cl solid electrolyte. Cells using the LiPOF-coated NCM85 demonstrated significantly improved capacity retention over 200 cycles, outperforming cells using uncoated NCM85.

Dibenzoperioctacene (DBPO) with extended zigzag edges was synthesized and characterized. While the bond length analysis indicated a possible open-shell nature of DBPO, variable-temperature NMR analysis indicated its closed-shell character. The theoretical investigations revealed the DBPO has nearly degenerate closed-shell and open-shell singlet states with a large singlet-triplet energy gap.

Nanographenes including 3D graphene, graphene quantum dots and graphene nanoribbons are among the fastest-growing materials used for the oxygen reduction reaction (ORR). The enhanced ORR activity of the nanographenes are original from the heteroatom doping effect, size effect, defects effect, and/or their synergistic effect, which can efficiently modify the charge distribution, optimize intermediate adsorption and accelerate electron transfer steps.

A photocatalytic Cloke-Wilson rearrangement of crude aminocyclopropane carboxylate (ACPC) imines is reported. This leverages an energy-transfer mechanism transforming the core of ACPC to value added dehydroprolines—a useful synthetic intermediate en route to the synthesis of substituted unnatural proline derivatives. Both the 1,5-dehydroproline, as well as the uncommon 1,2-isomer are obtained from the same starting material under slightly modified conditions.

Co single-atom catalyst with an unsymmetric Co-N₄P₁ coordination configuration is developed by tailoring second coordination sphere. Due to the greatly improved H₂ dissociation and product desorption, the catalyst exhibits superior activity, selectivity and stability for hydrogenation of halogenated nitroarenes to corresponding amines (20 examples, >99 % yields) at 80 °C under 0.5 MPa H₂ pressure.

A self-assembled monolayer (SAM) on the surface of LLZTO powders is constructed to inhibit the Li⁺/H⁺ exchange reaction and provide extra Lewis acid-base site, which achieving the establishment of a long-term local conducive microenvironment of Li⁺ conduction on the surface of LLZTO. This work emphasizes the importance of modulating solvation structure for the hybrid quasi-solid electrolyte.

Cell-sensing analogue nanopore (CeSa-nanopore) captures SARS-CoV-2 by specific receptor proteins ACE2 and changes the charge on the outer surface of the nanopore to enable the detection of SARS-CoV-2. This method eliminates the need for sample pre-treatment, enables rapid target detection, and allows for the detection of different targets by changing the cell membrane.

A novel fully conjugated covalent triazine-based hollow nanotube (CTN-1) with rich active sites and high surface areas has been prepared for piezocatalytic H₂O₂ evolution. Benefiting from piezoelectric response and fully conjugated framework, CTN-1 facilitated piezoelectric carrier separation, leading to highly efficient H₂O₂ production with a rate of 4115 μmol g⁻¹ h⁻¹, which is superior to other piezoelectric materials.

A new synthetic route for hydrogen isotope exchange (HIE) in arenes has been developed using catalytic PF₆⁻ in deuterated hexafluoroisopropanol and D₂O under mild conditions. This method achieves high yields and excellent deuterium incorporation in phenols, anisoles, anilines, and heteroaromatic substrates. An extended H-bonding network is responsible for activating the inert P−F bond in PF6⁻, allowing for HIE and the creation of deuterated compounds.

Self-assembly of iron(II) centers with phenyl isonicotinate and octacyanidorhenate(V) leads to a polar molecule-based material incorporating heterometallic Fe(II)−Re(V) cyanido-bridged chains. It exhibits a thermally induced cooperative spin crossover (high-spin-to-low-spin) transition on Fe(II) sites which results in remarkable thermal bistability of magnetic, visible-light absorption, second-harmonic generation, and dielectric properties.

A new and simple methodology to mechanically addressable molecular conductance switches with large conductance variations (~10³) between high- and low-G states is presented. By chemical design, rotational flexibility in these molecules and variable anchor group distances are translated into distinct conductance pathways for the different conformers of the same single molecule.

The structure-dependent electrochemical performance and the underlying catalytic mechanisms are still not clearly distinguished toward oxygen evolution reaction (OER). Herein, we synthesized ultrathin Co_6.8Se₈ nanosheets with subnanometer thickness by incorporating catalytically inactive selenium into ultrathin Co(OH)₂, thereby switching the OER reaction pathway from adsorbate evolution mechanism (AEM) to oxide path mechanism (OPM).

The geometrical reinforcement of chiral carbon cages by supramolecular technique led to enhancement of sensitivity against circularly polarized red light with an improved dissymmetry factor where the achiral guests such as Ar, CO₂, and CH₃CN are engaged in inhibition of undesired arrangement of transition dipole moments.

We report a Cl⁻-assisted active site transfer strategy on Ru_0.1Mn_0.9O_x, achieving high OER selectivity and long-term stability in acidic seawater. Typically, *Cl occupies the Ru site, shifting the OER center to CER-insensitive Mn, preventing metal site dissolution. Additionally, the active Mn sites create an environment that favors OER over CER, offering a selective and durable solution for acidic seawater electrolysis.

We design a TadA8.20-assisted N⁶-methyladenosine RNA imaging at single-base resolution (TARS) method for in situ visualization of both A and m⁶A forms at specific RNA sites within single cells. This method enables the quantification of m⁶A modification fractions, providing precise and detailed insights into m⁶A modifications at the single-base level.

Chemoenzymatic synthesis of cyclopiane and related diterpenes has been achieved in a three-stage manner. Ten cyclopiane diterpenes were obtained by skeleton construction with an engineered heterologous host, followed by late-stage functionalization of rings A, B and D by direct redox operations, directed C−H activation and enzymatic oxidation. Varied cyclopiane-related skeletons were further obtained by chemical transformation and genome mining.

Stable CeF₃@Ni₃N heterostructure with abundant interfaces is fabricated, which exhibits high electrocatalytic activity and stability under industrial current density for methanol upgrading coupled with hydrogen production. CeF₃@Ni₃N heterostructure can adjust electron distribution and modulate surface adsorption kinetics/capability of methanol and OH⁻, which is conducive to enhanced methanol oxidation reaction activity and selectivity.

Different counterions modulate the solid-state SO₂ adsorption behavior in M₆L₈ Metal-Organic Cages (M=Pd(II), Co(II), Cu(II), Zn(II)). Certain anions induce reversible SO₂-adsorption, while nitrate promotes its transformation to sulfate at room temperature. Among these cages, Pd₆L₈ exhibits the highest cavity-mediated SO₂ conversion, excellent stability, and is quantitatively regenerated.

An innovative crystal modulation strategy was proposed and implemented on a Mn-based cathode Na_0.72Li_0.24Mn_0.76O₂ with highly exposed {010} active facets and reinforced Mn−O bond, facilitating enduring anionic redox activity with fast kinetics. The robust structural stability and zero-strain behavior with ultra-low volume variation (0.1 C: 1.75 %, 1 C: 0.31 %, 5 C: 0.04 %) are directly revealed via advanced nondestructive time-resolved operando 2D-XRD.

Two isostructural lanthanide-nickel clusters Ln₁₃₂Ni₇₈ (Ln=Gd, Eu) were synthesized by the co-hydrolysis of Ln³⁺ and Ni²⁺ in the presence of iminodiacetate. Both clusters feature a hollow truncated tetrahedral structure with trumpet-shaped passageways that connect the exterior and the interior of the cluster cage. The solution-stable cluster has been shown to catalyze size-selective Knoevenagel condensation and one-pot three-component synthesis of 4H-pyran derivatives.

Switching residues: Adding new substituents to natural products increases their molecular weight and often their lipophilicity. We developed a Pd-catalysed protocol to directly replace the rhamnoside-arene fragment of the antibiotic fidaxomicin with simple amines in 1 step from the unprotected natural product. This enabled direct access to Fdx derivatives of reduced complexity with activity against RNA polymerase and various bacteria.

The structurally constrained, cationic P^III compound with the OCO dianionic pincer-type ligand [LP][SbCl₄] was prepared in a single step via the Sb-to-P metathesis reaction of the LSb-Cl with PCl₃. The preliminary reactivity of [LP][SbCl₄] with water, ammonia, and amines showed that the [SbCl₄]⁻ is not innocent in these reactions. Changing the [SbCl₄]⁻ to [Cb]⁻ anion, rerouted the reactivity of the resulting [LP][Cb] with water, alcohols, ammonia, and amines to the [LP]⁺ cation only. In the case of PhOH and PhNH₂ activation, the reactions were found to be thermoneutral.

A novel photocatalysis combined with cascade hydrogen atom transfer cycles for the carboxylation of benzylic tertiary C−H bond with CO₂ is reported. The power of this strategy is demonstrated for the late-stage carboxylation of broad bioactive molecule derivatives to obtain benzylic all-carbon quaternary carboxylic acids.

The exchange of high-spin Mn²⁺ into Ni−O−Ni nodes induced Jahn–Teller lattice distortion at adjacent Ni sites, significantly enhancing CO₂ photoreduction by promoting CO₂ adsorption through enhanced orbital overlap and facilitating charge carrier migration via additional spin-polarized electrons.

The β-ketoacyl synthase (KS) domain of metazoan fatty acid synthase catalyzes the condensation reaction of an acyl and malonyl substrate with two cooperatively working subunits. The KS ensures the fidelity of the fatty acid biosynthesis i) by increasing the speed with substrate length and ii) by discriminating against the intermediates of the fatty acid cycle.

Biogenetical CdS nanoparticles were integrated with Shewanella oneidensis biofilm to be capable of sustainable plastic-to-hydrogen production under the air. The upper section of the Figure illustrates the process of mineralized biofilm formation, and the lower section depicts the hydrogen production procedure from the mineralized biofilm through plastic degradation.

Slow down: Photo-crosslinking is used to mitigate the dissolution and degradation of natural fatty acids in a body fluid mimic, achieving sustained release in cells with controllable kinetics for drug delivery, nanomedicine, and related applications.

This minireview focuses on the analysis of the buried interface instability mechanisms of self-assembled monolayers (SAMs) in inverted perovskite solar cells, and highlights representative work to improve their stability. It also proposes potential strategies in material design and processing methods for achieving excellent stability in highly efficient SAM-based inverted devices.

Chemical recycling of phosphoric acid (H₃PO₄) recovered from sewage sludge ash into valuable phosphate triesters has been achieved via a novel esterification method with tetraalkyl orthosilicate. The approach offers an innovative recycling pathway, producing key industrial phosphorus chemicals without the use of white phosphorus while addressing phosphorus resource limitations and environmental impact.

Methanolation of olefins—the one-pot 100 % atom efficient addition of methanol to olefins yielding C1 elongated alcohols—is achieved using an integrated catalytic system based on the combination of organometallic Mn/pincer and Rh/phosphine catalysts.

A stable dicyclopenta[4,3,2,1-cde:4′,3′,2′,1′-pqr]-peri-tetracene derivative was successfully synthesized that shows global anti-aromaticity with small diradical character. The dication exhibits an open-shell diradical character and a unique [14]annulene-within-[22]annulene global aromatic structure, while the dianion is a closed-shell singlet in the ground state and displays a diatropic ring current on the π-conjugated periphery.

An autocatalytic chemical reaction network (CRN) has been developed that enables efficient control over sol(I)-gel and gel-sol(II) transitions through autocatalytic fronts. This approach, supported by a reaction-diffusion model, provides a theoretical framework for system preprogramming and demonstrates the potential for reversible, repeatable sol-gel transitions, shaping new frontiers in material science and bioengineering.

This review summarizes recent advancements in DNA tile and DNA origami-based 2D and 3D crystal lattice assemblies. It covers innovations in monomer design, guest molecule incorporation, and inorganic coating techniques. Key focus areas include assembly strategies, functional properties, structural challenges, and insights for future applications in programmable materials.

Near-infrared Type-I photodynamic chemiluminescent-protein complex (HEDP_N) is designed which can be specifically activated by the tumor-overexpressed nitroreductase for chemiluminescence-guided PDT.

By tuning the size of the catalyst ligand, a mesoporous aromatic framework, PAF-333, was obtained. It was found that the steric hindrance of larger-sized ligands avoided the framework interpenetration. Thanks to its large pore volume (3.4 cm³ g⁻¹), it could adsorb 13.4 wt % of hydrogen at 77 K, 100 bar and 0.537 g g⁻¹ of methane at 298 K, 98 bar, making it an ideal candidate for large-scale on-board methane storage.

The delivery of anion relay transporters across lipid membranes using a synthetic flippase is reported. These second generation photo-responsive relays incorporate an aryl azopyrazole photo-switch enabling greatly improved reversible photo-switching of the ion transport activity in situ, in real time.

A novel benzothiadiazole-fused cyanoindone (BTC) unit with ultra-strong electron-withdrawing ability was designed to synthesize an ultra-narrow bandgap acceptor BTC-2. Benefiting from long-range ordered stacking induced by BTC, PM6 : BTC-2 based organic photovoltaic device delivered a 17.17 % efficiency with a photocurrent of 30.34 mA cm⁻², and achieved a light utilization efficiency of 4.88 % in binary semi-transparent application.

Here, we present a rare instance of a soluble high-nuclearity polyoxometalate exhibiting Zn²⁺-triggered structural transformation from 0D nanocluster to 2D layer in ZnSO₄ solution. Further, we showcase that such a kind of polyoxometalate, possessing Zn²⁺-triggered structural transformation properties, represents a new-type and promising class of additives for aqueous zinc battery electrolytes with significant potential applications.

The sluggish redox kinetics of polysulfides significantly impeded the performance of sulfur-based aqueous batteries (SABs). We proposed an effective redox regulation strategy via a thiosulfate-mediated ligand-chain interaction within the K₂S₂O₃ electrolyte, which accelerates the polysulfide redox process (S⁰/S²⁻) and provides an additional capacity contribution through the thiosulfate redox pair (S₂O₃²⁻/S₄O₆²⁻). The thiosulfate-mediated SAB exhibits an unprecedented K⁺ storage capacity of 2470 mAh g⁻¹ and a high energy density of 616 Wh kg_S+Zn⁻¹, surpassing both organic K–S batteries and conventional aqueous battery systems.

An anthrazoline-based supramolecular photocatalyst (SA-SADF-H⁺) with an unsymmetric protonation structure significantly boosts H₂O₂ production from water and air. This design enhances charge separation and promotes dual active sites for Yeager-type O₂ adsorption, enabling a selective one-step two-electron ORR pathway. SA-SADF-H⁺ shows an H₂O₂ rate of 4666.7 μmol L⁻¹ h⁻¹ and 100 % antibacterial efficiency against Staphylococcus aureus.

We discovered a new multi-element catalyst (Ag₂Pt₃TiS₆) with enhanced ammonia oxidation reaction and oxygen reduction reaction mass activities compared to Pt/C. Through density functional theory calculations, we identify that this arises from active site motifs consisting of Pt and Ti atoms that work cooperatively. The bifunctional capability of Ag₂Pt₃TiS₆ is demonstrated as both the cathode and anode in a direct ammonia fuel cell.

Employing the site-specific functionalization strategy, a radially conjugated, helical tubular molecule has been constructed by covalently connecting [9]cycloparaphenylenes with three sp-hybridized all-carbon linkers. This compound exhibits intriguing solid-state packing patterns, exceptional CPL characteristics, and facile post-functionalization.

The Ni₃N@W₅N₄ nano-heterostructure catalyst, with built-in interfacial electric field and ultra-thin W₅N₄ shells, significantly enhances alkaline hydrogen evolution reaction kinetics involved in anion exchange membrane water electrolysis by reducing energy barriers and demonstrating excellent performance and stability.

A new rich nitrogen triazole-based monomer was used to fabricate two highly crystalline, porous and robust polyimide COFs with high-density redox-active groups through a flux synthesis method for proton batteries. The COF electrodes delivered a high reversible capacity, superior rate performance, and outstanding long-term stability, and the full cell with the COF anode and the MnO₂ cathode achieved both a high energy and power density.

Vacancy engineered polymeric carbon nitride nanosheets were developed as highly efficient heterogeneous photocatalysts for the diverse functionalization of electronic-rich alkenes.

Through-space charge transfer (TSCT) materials show potential for optoelectronic applications. This study unravels how spatial configuration impacts TSCT properties. Different photophysical properties were observed in a series of spiro-based TSCT materials. Their external quantum efficiencies range from 28.0 % to 3.6 %, highlighting the importance of spatial arrangement.

We report an organic molecule functionalization strategy to boost selectivity towards CO₂R and suppress HER over a range of catalysts including Bi, Cu and Zn. With a functionalized Bi catalyst, we attained a formate Faradaic efficiency of 85.8 % with dilute feedstock (15 % CO₂) at 100 mA cm⁻². Using an electrolyzer with a porous solid electrolyte layer, we successfully showcase 30 h of continuous high-purity formic acid production from dilute CO_2.

In this work, we prepare an AuAg alloy nanocluster ligated by carbene, [Au₁₃Ag₁₂(PPh₃)₈(BMIm)₂I₈]SbF₆, which is the first of its kind to show higher thermostability and higher sensitivity to light. It is attributed to a unique delocalization of electrons within the frontier orbitals. The Au₁₃Ag₁₂ : BMIm anchored on NiFe-LDH exhibits remarkable electrocatalytic activity in the electrosynthesis of urea.

A two-enzyme-catalyzed dynamic kinetic resolution (DKR) of racemic secondary alcohols in water—a ′Holy Grail of DKR′—was accomplished using an engineered alcohol dehydrogenase (ADH) for racemization through a hydrogen-borrowing sequence and variants of the acyltransferase from Mycobacterium smegmatis (MsAcT) for enantioselective acylation.

By using a novel search strategy, we identified common mild nonenzymatic conditions for all hydration reactions in gluconeogenesis and the rTCA cycle and for the retro-aldol cleavage of citrate, advancing the search for an environment conducive to the nonenzymatic emergence of a protometabolism.

Non-thermal plasma discharge produced in the wake of charged microdroplets is found to facilitate catalyst-free radical mediated hydrazine cross coupling, as reported by Abraham K. Badu-Tawiah et al. in their Research Article (e202413122). Plasma–microdroplet fusion occurs online in a programmable reaction platform allowing direct process optimization and product validation via mass spectrometry.

Building functional fluorophores from a simple scaffold. In their Research Article (e202415627), Lei Zhang, Su Jing, Thorben Cordes, and co-workers use the Ugi-4-component reaction to assemble fluorogenic dye molecules that selectively localize to mitochondria or lysosomes. The multifunctional fluorophores are not only fluorogenic but also induce pyroptosis in living cancer cells. The study shows the potential of scaffold-based synthesis for creation of new functional fluorophores.

Spatially selective detection of metal ions in subcellular compartments has been achieved in the Research Article (e202412387) by Deyu Yi, Lele Li, and Mengyuan Li. This nanotechnology utilizes a specific ribosomal RNA to locally activate DNAzyme-based sensing function, driving multiple catalytic cleavage of molecular beacons for amplified metal-ion imaging in mitochondria.

Allosterically targeting CDC37 by small molecule inhibitor DDO-6079 disrupts protein-protein interaction of HSP90-CDC37 and CDC37-CDK4/6, thus to decrease thermal stability of CDK6 and reverse drug resistance of CDK4/6 inhibitors without HSR.

Highly crystalline two-dimensional conductive metal–organic framework, copper₃(hexaiminobenzene)₂ (Cu₃(HIB)₂), has been obtained through strategic synthetic modification. The Cu₃(HIB)₂ device shows ultrasensitive, highly selective, reversible, and low-power chemiresistive sensor for nitric oxide. Mechanistic investigation reveals the contribution of Cu-bis(iminobenzosemiquinoid) functionality of Cu₃(HIB)₂) for highly sensitive and reversible NO binding sites.

X-ray Diffraction Computed Tomography (XRD-CT) has been used to reveal pressure-induced phase transformations in pharmaceutical tablets of glycolide as a function of compaction pressure. Temporal analysis of the tablets, and subsequent identification using electron diffraction, revealed a hydrolysis reaction occurred on storage of the tablets. This reaction was enhanced in the presence of microcrystalline cellulose.

Utilizing seawater as an electrolyte enables efficient hydrogen peroxide production for coastal applications. The NO-DC₇₀₀ catalyst, synthesized via pyrolysis of silk, achieves 4997 mg L⁻¹ h⁻¹ H₂O₂ with a faradaic efficiency of 96.5 %, offering a sustainable and cost-effective method for on-site production in coastal region.

The electron count affects the shape of Bi₆^q− units, from a regular prism in Bi₆²⁻ (left) to a regular crown-type cycle in Bi₆⁶⁻ (right). Such units were previously isolated in the coordination sphere of metal complexes, while the (less symmetric) intermediate with a −4 charge has only been predicted by theory. In their Research Article (e202417234), Florian Weigend, Stefanie Dehnen et al. isolated the Zintl cluster [Bi₆{Zn(hmds)}₂]²⁻ (center), in which two 12-electron fragments are perfectly suited to stabilize the boat-type Bi₆⁴⁻ unit, as confirmed by DFT calculations.

Supramolecular helical pseudo-polycatenane polymers with controlled handedness are formed via the self-assembly of chirally twisted pseudo-macrocyclic tetrakisporphyrin monomers developed by Takeharu Haino et al. in their Research Article (e202416770). The cover illustrates the supramolecular polymerization of pseudo-macrocyclic tetrakisporphyrin monomers.

We have demonstrated a new approach of ΔE_ST modulation via the triplet blocking effect, achieving decreased S₁ but constant T₁ energy level. The conflict between small ΔE_ST and large oscillator strengths is relieved. The results are crucial for fundamental photophysics as well as development of optoelectronic materials.

Sulfoximine substituted bicyclo[1.1.0]butanes are prepared in one-pot and then diversified through 3 vectors. N-Functionalization allows controlled variation in the electrophilicity of the BCB in strain release processes including in protein labelling under biocompatible conditions, and the proximal stereocenter allows stereoselective protein labelling.

The electrode potential adjust the interaction between active sites and intermediates for enhancing NO-to-NH₃ conversion over V_O−TiO_2−x.

Bis(arene) coordination compounds of zirconium and hafnium have been synthesized in high yield by 4e reduction of tetrachloride adducts with a germylene phosphine Lewis pair. A puckered coordination mode of an arene moiety is discussed based on structural and spectroscopic data. Carbonyl complexes were synthesized. Dimethylbutadiene reacts under formation of a cyclohexadienyl and a triorganogermate ligand. This addition is reversible at room temperature in the zirconium case.

A new Pt(II) starting material is cheap and easy to make, with exceptional air stability. It was used to synthesise [Pt₂L₄]⁴⁺ lantern-shaped cages including their first heteroleptic, low-symmetry and multicavity examples.

The metastable hexagonal Rh nanocrystal catalyst is synthesized via interstitial boron insertion for alkaline hydrogen oxidation reaction (HOR). The insertion of boron atoms into Rh lattice not only induces phase transition from face-centered cubic to hexagonal close-packed, but also optimized adsorbed behaviors of reaction intermediates, leading to improved connectivity of hydrogen-bond networks and enhanced HOR performance.

Combining molecular dynamics simulations and density functional theory calculations, we inspected the molecular-scale impact that a benzotriazole-based 3D four-arm small molecule has on the local morphology and electronic properties of PM6 : Y6 blends. Detailed examination of these aspects allowed us to highlight key requirements that the electronic properties of 3D multi-arm small molecules need to fulfill in order to improve device efficiency.

An exploration of 1,2-dihydroazetes in ring-opening metathesis polymerization (ROMP) is reported. The 4-membered rings readily polymerized using the Hoveyda-Grubbs 2^nd generation initiator and maintained living chain-ends for block polymer synthesis. This study gives new insights into the reactivity and limitations of enamine derivatives in metathesis processes, while also offering a new approach to degradable metathesis materials with tunable properties.ROMP1,2-DihydroazeteDegradationRegio-selectivity

A method for direct benzylic C(sp³)−H phosphonylation of non-specialized alkylarenes is reported. This dehydrogenative C−P bond formation method features high step economy and takes place under mild reaction conditions, which enables good functional group tolerance. Mechanistic studies indicate that the reaction proceeds via intermolecular hydrogen atom abstraction and operates by a radical pathway.