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    Annals of Neurology: Volume 88, Issue 5

    i-vi, 863-1057
    November 2020
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Free Access

Annals of Neurology: Volume 88, Number 5, November 2020

  • First Published: 22 October 2020

Issue Information

Free Access

Issue Information

  • Pages: i-vi
  • First Published: 22 October 2020

Editorial

The New Normal in Clinical Trials: Decentralized Studies

E. Ray Dorsey MD,  Benzi Kluger MD, MS,  Craig H. Lipset MPH, 
  • Pages: 863-866
  • First Published: 31 August 2020

Research Articles

Open Access

Loss-of-Function Variants in HOPS Complex Genes VPS16 and VPS41 Cause Early Onset Dystonia Associated with Lysosomal Abnormalities

Dora Steel MD,  Michael Zech MD,  Chen Zhao PhD,  Katy E. S. Barwick PhD,  Derek Burke PhD,  Diane Demailly MD,  Kishore R. Kumar FRACP,  Giovanna Zorzi MD,  Nardo Nardocci MD,  Rauan Kaiyrzhanov MD,  Matias Wagner MD,  Arcangela Iuso PhD,  Riccardo Berutti PhD,  Matej Škorvánek MD, PhD,  Ján Necpál MD,  Ryan Davis PhD,  Sarah Wiethoff MD, PhD,  Kshitij Mankad FRCR,  Sniya Sudhakar,  Arianna Ferrini PhD,  Suvasini Sharma DM,  Erik-Jan Kamsteeg PhD,  Marina A. Tijssen MD, PhD,  Corien Verschuuren MD,  Martje E. van Egmond MD, PhD,  Joanna M. Flowers PhD,  Meriel McEntagart MD,  Arianna Tucci PhD,  Philippe Coubes MD, PhD,  Bernabe I. Bustos PhD,  Paulina Gonzalez-Latapi MD,  Stephen Tisch FRACP,  Paul Darveniza FRACP,  Kathleen M. Gorman MD,  Kathryn J. Peall BMBCh, PhD,  Kai Bötzel MD,  Jan C. Koch MD,  Tomasz Kmieć MD, PhD,  Barbara Plecko MD, Professor of Pediatrics,  Sylvia Boesch MD,  Bernhard Haslinger MD,  Robert Jech MD,  Barbara Garavaglia PhD,  Nick Wood PhD,  Henry Houlden MD,  Paul Gissen MD, PhD,  Steven J. Lubbe PhD,  Carolyn M. Sue MB.,BS PhD,  Laura Cif MD, PhD,  Niccolò E. Mencacci MD, PhD,  Glenn Anderson FIBMS,  Manju A. Kurian PhD,  Juliane Winkelmann MD,  Genomics England Research Consortium , 
  • Pages: 867-877
  • First Published: 18 August 2020

Plasma NT1 Tau is a Specific and Early Marker of Alzheimer's Disease

David Mengel MD,  Shorena Janelidze PhD,  Robert J. Glynn ScD,  Wen Liu BSc,  Oskar Hansson MD, PhD,  Dominic M. Walsh PhD, 
  • Pages: 878-892
  • First Published: 23 August 2020

Dopaminergic Retinal Cell Loss and Visual Dysfunction in Parkinson Disease

Isabel Ortuño-Lizarán PhD,  Xavier Sánchez-Sáez MSc,  Pedro Lax PhD,  Geidy E. Serrano PhD,  Thomas G. Beach MD, PhD,  Charles H. Adler MD, PhD,  Nicolás Cuenca PhD, 
  • Pages: 893-906
  • First Published: 03 September 2020

Sleep Disruption in Epilepsy: Ictal and Interictal Epileptic Activity Matter

Laure Peter-Derex MD, PhD,  Petr Klimes PhD,  Véronique Latreille PhD,  Sarah Bouhadoun MDCM IV,  François Dubeau MD,  Birgit Frauscher MD, 
  • Pages: 907-920
  • First Published: 24 August 2020

Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline

Rachel F. Buckley PhD,  Matthew R. Scott BA,  Heidi I. L. Jacobs PhD,  Aaron P. Schultz PhD,  Michael J. Properzi BEng,  Rebecca E. Amariglio PhD,  Timothy J. Hohman PhD,  Danielle V. Mayblyum BS,  Zoe B. Rubinstein BA,  Lyssa Manning MA,  Bernard J. Hanseeuw MD, PhD,  Elizabeth C. Mormino PhD,  Dorene M. Rentz PhD,  Keith A. Johnson MD,  Reisa A. Sperling MD, 
  • Pages: 921-932
  • First Published: 16 August 2020

Transcranial Magnetic Stimulation Promotes Gait Training in Parkinson Disease

Chloe Lau-Ha Chung PhD,  Margaret Kit-Yi Mak PhD,  Mark Hallett MD, DM, 
  • Pages: 933-945
  • First Published: 22 August 2020

Implantable Cardiac Monitoring in the Secondary Prevention of Cryptogenic Stroke

Sokratis Triantafyllou,  Aristeidis H. Katsanos,  Polychronis Dilaveris,  Georgios Giannopoulos,  Charalampos Kossyvakis,  Elias Adreanides,  Chrissoula Liantinioti,  Konstantinos Tympas,  Christina Zompola,  Aikaterini Theodorou,  Lina Palaiodimou,  Panagiota Flevari,  Maria Kosmidou,  Konstantinos Voumvourakis,  John Parissis,  Spyridon Deftereos,  Georgios Tsivgoulis, 
  • Pages: 946-955
  • First Published: 22 August 2020

Deep Brain Stimulation for Chronic Cluster Headache: Meta-Analysis of Individual Patient Data

Andreas Nowacki MD,  Martin Schober BMed,  Lydia Nader MD,  Assel Saryyeva MD,  Thuy-Anh Khoa Nguyen PhD,  Alexander L. Green MD,  Claudio Pollo MD,  Joachim K. Krauss MD,  Denys Fontaine MD, PhD,  Tipu Z. Aziz FMedSc, 
  • Pages: 956-969
  • First Published: 22 August 2020

Temporal Lobe Epilepsy Surgical Outcomes Can Be Inferred Based on Structural Connectome Hubs: A Machine Learning Study

Ezequiel Gleichgerrcht MD, PhD,  Simon S. Keller PhD,  Daniel L. Drane PhD,  Brent C. Munsell PhD,  Kathryn A. Davis MD,  Erik Kaestner PhD,  Bernd Weber MD, PhD,  Samantha Krantz BSc,  William A. Vandergrift,  Jonathan C. Edwards MD, MBA,  Carrie R. McDonald PhD,  Ruben Kuzniecky MD,  Leonardo Bonilha PhD, 
  • Pages: 970-983
  • First Published: 22 August 2020

Association of Plasma Neurofilament Light with Postoperative Delirium

Tamara G. Fong MD, PhD,  Sarinnapha M. Vasunilashorn PhD,  Long Ngo PhD,  Towia A. Libermann PhD,  Simon T. Dillon PhD,  Eva M. Schmitt PhD,  Alvaro Pascual-Leone MD, PhD,  Steven E. Arnold MD,  Richard N. Jones ScD,  Edward R. Marcantonio MD, SM,  Sharon K. Inouye MD, MPH,  for the SAGES Study Group , 
  • Pages: 984-994
  • First Published: 03 September 2020

Functional Connectivity Decreases with Metabolic Stress in Sickle Cell Disease

Melanie E. Fields MD, MSCI,  Amy E. Mirro MEng,  Kristin P. Guilliams MD, MSCI,  Michael M. Binkley PhD,  Luisa Gil Diaz BSc,  Jessica Tan BA,  Slim Fellah PhD,  Cihat Eldeniz PhD,  Yasheng Chen DSc,  Andria L. Ford MD, MSCI,  Joshua S. Shimony MD, PhD,  Allison A. King MD, PhD,  Hongyu An DSc,  Christopher D. Smyser MD, MSCI,  Jin-Moo Lee MD, PhD, 
  • Pages: 995-1008
  • First Published: 31 August 2020

Sensitivity–Specificity of Tau and Amyloid β Positron Emission Tomography in Frontotemporal Lobar Degeneration

Alma Ghirelli MD,  Nirubol Tosakulwong BS,  Stephen D. Weigand MS,  Heather M. Clark PhD,  Farwa Ali MD,  Hugo Botha MD,  Joseph R. Duffy PhD,  Rene L. Utianski PhD,  Marina Buciuc MD,  Melissa E. Murray PhD,  Sydney A. Labuzan MS,  Anthony J. Spychalla BS,  Nha Trang Thu Pham BS,  Christopher G. Schwarz PhD,  Matthew L. Senjem MS,  Mary M. Machulda PhD,  Matthew Baker BS,  Rosa Rademakers PhD,  Massimo Filippi MD,  Clifford R. Jack Jr MD,  Val J. Lowe MD,  Joseph E. Parisi MD,  Dennis W. Dickson MD,  Keith A. Josephs MD, MST, MSc,  Jennifer L. Whitwell PhD, 
  • Pages: 1009-1022
  • First Published: 31 August 2020

Brief Communications

Effects of IgLON5 Antibodies on Neuronal Cytoskeleton: A Link between Autoimmunity and Neurodegeneration

Jon Landa MSc,  Carles Gaig MD, PhD,  Jesús Plagumà PhD,  Albert Saiz MD, PhD,  Ana Antonell PhD,  Raquel Sanchez-Valle MD, PhD,  Josep Dalmau MD, PhD,  Francesc Graus MD, PhD,  Lidia Sabater PhD, 
  • Pages: 1023-1027
  • First Published: 02 August 2020

Early-Onset Parkinsonism Is a Manifestation of the PPP2R5D p.E200K Mutation

Christine Y. Kim MD,  Thomas Wirth MD, MS,  Cécile Hubsch MD, PhD,  Andrea H. Németh MB.BS, DPhil,  Volkan Okur MD,  Mathieu Anheim MD, PhD,  Nathalie Drouot MS,  Christine Tranchant MD, PhD,  Gabrielle Rudolf PhD,  Jamel Chelly MD, PhD,  Katrina Tatton-Brown MD,  Cornelis Blauwendraat PhD,  Jean Paul G. Vonsattel MD,  Etty Cortes MD,  Roy N. Alcalay MD, MS,  Wendy K. Chung MD, PhD, 
  • Pages: 1028-1033
  • First Published: 03 August 2020

Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study

Pietro Maggi MD, PhD,  Pascal Sati PhD,  Govind Nair PhD,  Irene C. M. Cortese MD,  Steven Jacobson PhD,  Bryan R. Smith MD,  Avindra Nath MD,  Joan Ohayon CRNP,  Vincent van Pesch MD, PhD,  Gaetano Perrotta MD,  Caroline Pot MD, PhD,  Marie Théaudin MD,,  Vittorio Martinelli MD,  Roberta Scotti MD,  Tianxia Wu PhD,  Renaud Du Pasquier MD,  Peter A. Calabresi MD,  Massimo Filippi MD,  Daniel S. Reich MD, PhD,  Martina Absinta MD, PhD, 
  • Pages: 1034-1042
  • First Published: 15 August 2020
Open Access

Evaluating Lipid-Lowering Drug Targets for Parkinson's Disease Prevention with Mendelian Randomization

Dylan M. Williams PhD,  Sara Bandres-Ciga PhD,  Karl Heilbron PhD,  David Hinds PhD,  Alastair J. Noyce MRCP, PhD,  The 23andMe Research Team ,  The International Parkinson's Disease Genomics Consortium , 
  • Pages: 1043-1047
  • First Published: 25 August 2020

Neuro-Images

Intraspinal Gouty Tophus

Meng Si MD,  Menglin Cong MD,  Dandan Wang BD,  Hecheng Ma MD, 
  • Pages: 1048-1049
  • First Published: 09 August 2020

Silicone Oil: A Mimicker of Intraventricular Hemorrhage

Haroon Butt MD,  Mohammad Siraj Qadir MD,  Gabriel Torrealba-Acosta MD, MSc, 
  • Pages: 1050-1051
  • First Published: 24 August 2020

Letters/Replies

Chronic Traumatic Encephalopathy and Primary Age-Related Tauopathy

Yi-He Chen,  Qing-Qing Tao, 
  • Pages: 1052
  • First Published: 02 August 2020

Reply to “Chronic Traumatic Encephalopathy and Primary Age-Related Tauopathy”

Jesse Mez MD, MS,  Daniel H. Daneshvar MD, PhD,  Michael L. Alosco PhD,  Victor E. Alvarez MD,  Bertrand R. Huber MD, PhD,  Thor D. Stein MD, PhD,  Ann C. McKee, 
  • Pages: 1052-1053
  • First Published: 04 August 2020

Concerning Vision Therapy and Ocular Motor Training in Mild Traumatic Brain Injury

Janet C. Rucker MD,  John-Ross Rizzo MD,  Todd E. Hudson PhD,  Laura J. Balcer MD,  Steven L. Galetta MD, 
  • Pages: 1053-1054
  • First Published: 15 August 2020

Reply to “Concerning Vision Therapy and Ocular Motor Training in Mild TBI”

Jason J. S. Barton MD, PhD, FRCPC,  Paul J. Ranalli MD, FRCPC, 
  • Pages: 1054-1055
  • First Published: 15 August 2020

Correction

Free Access

Correction to: “Optimizing Patient Selection for Endovascular Treatment in Acute Ischemic Stroke (SELECT): A Prospective Multicenter Cohort Study of Imaging Selection”

Amrou Sarraj MD,  Ameer E. Hassan DO,  James Grotta MD,  Clark Sitton MD,  Gary Cutter PhD,  Chunyan Cai PhD,  Peng R. Chen MD,  Bita Imam PhD,  Deep Pujara MD,  Ashish Arora MD,  Sujan Reddy MD,  Kaushik Parsha MD,  Roy F Riascos MD,  Nirav Vora MD,  Michael Abraham MD,  Randall Edgell MD,  Frank Hellinger MD,  Diogo C. Haussen MD,  Spiros Blackburn MD,  Haris Kamal MD,  Andrew D. Barreto MD,  Sheryl Martin-Schild MD,  Maarten Lansberg MD,  Rishi Gupta MD,  Sean Savitz MD,  Gregory W. Albers MD,, 
  • Pages: 1056-1057
  • First Published: 20 August 2020