• Issue
    Volume 6, Issue 4
    April 2023

Cover Picture

Free Access

In Vitro Cytostatic Effect on Tumor Cells by Carborane-Based Dual Cyclooxygenase-2 and 5-Lipoxygenase Inhibitors (Adv. Therap. 4/2023)

  • First Published: 13 April 2023
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Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) are key enzymes in the biosynthesis of pro-inflammatory and tumor-inducing eicosanoids. Thus, dual COX-2/5-LO inhibition may represent a promising strategy to prevent the pathogenesis of cancer and for cancer treatment. The bioisosteric replacement of the fluorophenyl moiety in RWJ-63556 by meta- or para-carborane results in potent derivatives showing dual COX-2/5-LO inhibitory and antitumor activity. This is reported by Evamarie Hey-Hawkins and co-workers in article number 2200252.

Back Cover

Free Access

Development of a Clinically Viable Strategy for Nanoparticle-Based Photodynamic Therapy of Colorectal Cancer (Adv. Therap. 4/2023)

  • First Published: 13 April 2023
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This image depicts the potential role of photodynamic therapy in treating colorectal cancer. With the use of porphysome nanoparticles, the authors envision a future where patients can receive outpatient neoadjuvant cancer treatment. In article number 2200342, Keegan Guidolin, Lili Ding, Juan Chen, and Gang Zheng demonstrate orthotopic disease treated in-situ in the rectum of rodents and provide an important step in the translation of nanomedicine.

Masthead

Free Access

Masthead (Adv. Therap. 4/2023)

  • First Published: 13 April 2023

Reviews

Drug Permeability: From the Blood–Brain Barrier to the Peripheral Nerve Barriers

  • First Published: 18 January 2023
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The molecular, structural, and functional similarities and differences between the blood–brain barrier and peripheral nerve barrier are described, existing central nervous system (CNS) and peripheral nerve drug delivery strategies are summarized and compared, and the potential application of selected CNS delivery strategies to improve efficacious drug entry for peripheral nerve disorders is discussed.

DNA Nanogel for Cancer Therapy

  • First Published: 01 February 2023
Description unavailable

This review focuses on DNA nanogels based on pure DNA materials and these DNA nanogels are categorized into two types depending on their construction methods. Recent advances on the fabrication of DNA nanogels with high target ability and stimuli-responsive capability are summarized. Furthermore, emerging applications of DNA nanogels for improved cancer therapy are also discussed.

Establishments and Evaluations of Post-Operative Adhesion Animal Models

  • First Published: 04 February 2023
Description unavailable

Animal experiment plays a very important role in evaluating the performance of post-operative anti-adhesion materials, which are mainly classified into the establishment and evaluation of animal adhesion models. There are several methods to establish animal adhesion models at different sites. There are also various methods of evaluation from macroscopic to microscopic.

Research Articles

Open Access

In Vitro Cytostatic Effect on Tumor Cells by Carborane-Based Dual Cyclooxygenase-2 and 5-Lipoxygenase Inhibitors

  • First Published: 22 December 2022
Description unavailable

The incorporation of metabolically stable and highly hydrophobic carboranes into RWJ-63556, a dual inhibitor of cycloxygenase-2 (COX-2) and 5-lipoxygenase (5-LO), is investigated. Both enzymes are key mediators in the biosynthesis of pro-inflammatory and tumor-inducing eicosanoids. The replacement of the fluorophenyl moiety by meta- or para-carborane results in the first group of carborane-based dual COX-2/5-LO inhibitors as potent antitumor agents.

Open Access

Development of a Clinically Viable Strategy for Nanoparticle-Based Photodynamic Therapy of Colorectal Cancer

  • First Published: 19 January 2023
Description unavailable

Developing a clinically viable photodynamic therapy (PDT) strategy for nanoparticle-based PDT of colorectal cancer by optimizing drug administration method, drug-light interval, and light placement approach on three complimentary animal models of colorectal cancer.

A Calcium Alginate Hydrogel Microsphere-Based Transcatheter Arterial Viroembolization Strategy for Hepatocellular Carcinoma

  • First Published: 24 December 2022
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This article presents a novel, validated transcatheter arterial viroembolization strategy: a calcium alginate hydrogel microsphere with oncolytic adenoviruses (OAs) encapsulated to achieve a combination of transcatheter arterial embolization with oncolytic virotherapy to enhance and prolong antitumor efficacy of OA in hepatocellular carcinoma treatment, which have the potential as an effective embolic system for clinical cancer treatment.

Bilirubin Nanomedicine Alleviates Inflammation and Angiogenesis in a Rosacea Mouse Model

  • First Published: 30 December 2022
Description unavailable

Bilirubin-based nanoparticles (BRNPs) alleviate inflammation in the LL-37-induced rosacea mouse model. BRNPs reduce the reactive oxygen species in the skin lesion where inflammation is induced, and suppress subsequent pathological manifestation of rosacea by downregulating the expression of proinflammatory cytokines and chemokines and suppressing the expression of vascular endothelial growth factor and mast cell infiltration.

Open Access

Multicellular Quadruple Colorectal Cancer Spheroids as an In Vitro Tool for Antiangiogenic Potential Evaluation of Nanoparticles

  • First Published: 15 January 2023
Description unavailable

Colorectal cancer occupies the third position worldwide in terms of incidence and is the second cause of cancer-related deaths. Preclinical models that mimic the complexity of colorectal cancer are explored in the literature. This study takes an unprecedented approach to explore a quadruple co-culture model to evaluate the antiangiogenic activity of nanoparticles.

Dimeric Cholic Acid Peptide Conjugates Act as Effective Antibiotic Adjuvants against Multidrug Resistance (MDR) Gram-Negative Bacterial Infections

  • First Published: 04 February 2023
Description unavailable

Macrolide class of antibiotics like erythromycin is ineffective against Gram-negative bacteria. Here, it is shown that cholic acid-derived dimeric amphiphile potentiates the activity of erythromycin against Gram-negative bacteria, making it effective against biofilms and wound infections.

Functionalized Ionic Liquid Exfoliated MoS2 Nanosheets for Photoacoustic Imaging Guided Synergistic Photothermal/Chemotherapy

  • First Published: 28 January 2023
Description unavailable

Ionic liquid (IL) with antitumor activity is used to prepare high-quality, high-yield IL-MoS2 nanosheets. PEG-b-PIL improves the biocompatibility, stability, and photothermal effects of the nanosheets, making its photothermal conversion efficiency 70.98%. IL-MoS2-PEG-b-PIL@DOX is used for synergistic photothermal and chemotherapy to inhibit tumor growth and applications of photoacoustic and photothermal imaging. Therefore, IL-MoS2-PEG-b-PIL nanosheets have potential applications for cancer treatment.

A Multifunctional Nanoplatform for Tumor-Targeted Imaging and Enhanced Ferroptosis Therapy

  • First Published: 10 February 2023
Description unavailable

Schematic of a multifunctional nanoplatform based on fluorescent apoferritin-gold nanoclusters combined with glucose oxidase (AFt-AuNCs@GOx). Intracellular AFt-AuNCs@GOx induce an enhanced ferroptosis via the lipid peroxidation generation from the toxic ·OH. AFt-AuNCs@GOx affect genes expression related to ferroptosis and glutathione metabolism.Therefore, AFt-AuNCs@GOx integrate imaging, targeting, and ferroptosis therapy for tumor treatment.

Gold Nanocluster Encapsulated Nanorod for Tumor Microenvironment Simultaneously Activated NIR-II Photoacoustic/Photothermal Imaging and Cancer Therapy

  • First Published: 24 January 2023
Description unavailable

A gold nanocluster encapsulated nanorod is prepared as a smart nanoprobe for tumor microenvironment simultaneously activated NIR-II photoacoustic/photothermal imaging and cancer therapy. The nanoprobe combines gold nanorods and gold nanoclusters by sulfhydryl coupling, which results its photoacoustic/photothermal signals in normal tissues "off" and in tumor tissues "on." This work establishes an accurate integrated platform for nanodiagnosis and treatment of cancer.

Self-Delivery O2-Ecomonizer to Reverse Antiapoptosis of Hypoxic Tumor for Enhanced Photodynamic Therapy

  • First Published: 15 February 2023
Description unavailable

Chlorin e6 and Tamoxifen-based self-delivery O2-ecomonizer (CeTam) is developed for enhanced photodynamic therapy (PDT) by reducing cell respiration and Bcl-2 expression, which remedies the deficiencies of PDT on hypoxic tumor treatment.

Open Access

Bridging the Binding Sites: Dualsteric Ligands for the Cannabinoid 2 Receptor (CB2R)

  • First Published: 04 February 2023
Description unavailable

By chemical combination of an orthosteric ligand and a positive allosteric modulator for the cannabinoid receptor subtype 2 (CB2R), two sets of putatively heterobivalent, dualsteric ligands are obtained. The compounds are CB2R-selective. Investigation into G protein-signaling shows remarkable binding and signaling profiles, such as an efficacy higher than the reference compound's one (“superagonism”) of compounds of set B compounds.