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    2012
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Editorial
Open Access

Signals Regulating Adhesion Dynamics

Donna J. Webb,  Claire M. Brown,  Kris A. DeMali, 
  • First Published: 31 December 2012
Editorial
Open Access

Signal Transduction Alterations in Glioma: Implications for Diagnosis and Therapy

Laura Cerchia,  Juan-Carlos Martinez Montero,  Parisa Monfared, 
  • First Published: 09 December 2012
Research Article
Open Access

Commitment of Satellite Cells Expressing the Calcium Channel α2δ1 Subunit to the Muscle Lineage

Tammy Tamayo,  Liliana Grajales,  Jesús García, 
  • First Published: 29 November 2012
Review Article
Open Access

Protein-Tyrosine Kinase Signaling in the Biological Functions Associated with Sperm

Takashi W. Ijiri,  A. K. M. Mahbub Hasan,  Ken-ichi Sato, 
  • First Published: 11 November 2012
Research Article
Open Access

Levels of CaV1.2 L-Type Ca2+ Channels Peak in the First Two Weeks in Rat Hippocampus Whereas CaV1.3 Channels Steadily Increase through Development

Audra A. Kramer,  Nicholas E. Ingraham,  Emily J. Sharpe,  Michelle Mynlieff, 
  • First Published: 14 October 2012
Research Article
Open Access

Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells

Linda Yu,  Alicia B. Moore,  Lysandra Castro,  Xiaohua Gao,  Hoang-Long C. Huynh,  Michelle Klippel,  Norris D. Flagler,  Yi Lu,  Grace E. Kissling,  Darlene Dixon, 
  • First Published: 09 October 2012
Review Article
Open Access

Pathogenic Role of Store-Operated and Receptor-Operated Ca2+ Channels in Pulmonary Arterial Hypertension

Ruby A. Fernandez,  Premanand Sundivakkam,  Kimberly A. Smith,  Amy S. Zeifman,  Abigail R. Drennan,  Jason X.-J. Yuan, 
  • First Published: 27 September 2012
Review Article
Open Access

The Role of Semaphorins and Their Receptors in Gliomas

Janice Wai Sze Law,  Alan Yiu Wah Lee, 
  • First Published: 23 September 2012
Review Article
Open Access

RGD-Dependent Epithelial Cell-Matrix Interactions in the Human Intestinal Crypt

Yannick D. Benoit,  Jean-François Groulx,  David Gagné,  Jean-François Beaulieu, 
  • First Published: 05 September 2012
Review Article
Open Access

Involvement of Src in the Adaptation of Cancer Cells under Microenvironmental Stresses

A. K. M. Mahbub Hasan,  Takashi Ijiri,  Ken-ichi Sato, 
  • First Published: 03 September 2012
Research Article
Open Access

Prolonged Action Potential and After depolarizations Are Not due to Changes in Potassium Currents in NOS3 Knockout Ventricular Myocytes

Honglan Wang,  Ingrid M. Bonilla,  Xin Huang,  Quanhua He,  Mark J. Kohr,  Cynthia A. Carnes,  Mark T. Ziolo, 
  • First Published: 28 August 2012
Review Article
Open Access

The Role of HCN Channels on Membrane Excitability in the Nervous System

Daisuke Kase,  Keiji Imoto, 
  • First Published: 13 August 2012
Research Article
Open Access

Contractile Activity Regulates Inducible Nitric Oxide Synthase Expression and NOi Production in Cardiomyocytes via a FAK-Dependent Signaling Pathway

Miensheng Chu,  Yevgeniya Koshman,  Rekha Iyengar,  Taehoon Kim,  Brenda Russell,  Allen M. Samarel, 
  • First Published: 26 July 2012
Research Article
Open Access

Prolactin and Dexamethasone Regulate Second Messenger-Stimulated Cl− Secretion in Mammary Epithelia

Utchariya Anantamongkol,  Mei Ao,  Jayashree Sarathy nee Venkatasubramanian,  Y. Sangeeta Devi,  Nateetip Krishnamra,  Mrinalini C. Rao, 
  • First Published: 25 July 2012
Review Article
Open Access

Focal Adhesion Kinases in Adhesion Structures and Disease

Pierre P. Eleniste,  Angela Bruzzaniti, 
  • First Published: 19 July 2012
Review Article
Open Access

NPM-ALK: The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases

Joel D. Pearson,  Jason K. H. Lee,  Julinor T. C. Bacani,  Raymond Lai,  Robert J. Ingham, 
  • First Published: 18 July 2012
Review Article
Open Access

Angiogenic Signalling Pathways Altered in Gliomas: Selection Mechanisms for More Aggressive Neoplastic Subpopulations with Invasive Phenotype

Susana Bulnes,  Harkaitz Bengoetxea,  Naiara Ortuzar,  Enrike G. Argandoña,  Álvaro Garcia-Blanco,  Irantzu Rico-Barrio,  José V. Lafuente, 
  • First Published: 17 July 2012
Review Article
Open Access

DNA Methylation, Histone Modifications, and Signal Transduction Pathways: A Close Relationship in Malignant Gliomas Pathophysiology

Raúl Alelú-Paz,  Nadia Ashour,  Ana González-Corpas,  Santiago Ropero, 
  • First Published: 17 July 2012
Review Article
Open Access

Receptor Tyrosine Kinases: Molecular Switches Regulating CNS Axon Regeneration

Vasanthy Vigneswara,  Sarina Kundi,  Zubair Ahmed, 
  • First Published: 16 July 2012
Review Article
Open Access

The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses

Yusuke Kanamaru,  Shiori Sekine,  Hidenori Ichijo,  Kohsuke Takeda, 
  • First Published: 15 July 2012
Review Article
Open Access

Regulation of Adherens Junction Dynamics by Phosphorylation Switches

Cristina Bertocchi,  Megha Vaman Rao,  Ronen Zaidel-Bar, 
  • First Published: 12 July 2012
Research Article
Open Access

Elimination of the Actin-Binding Domain in Kelch-Like 1 Protein Induces T-Type Calcium Channel Modulation Only in the Presence of Action Potential Waveforms

Kelly A. Aromolaran,  Kelly A. Benzow,  Leanne L. Cribbs,  Michael D. Koob,  Erika S. Piedras-Rentería, 
  • First Published: 11 July 2012
Review Article
Open Access

Antiangiogenic Therapy for Glioma

Valentina Cea,  Carlo Sala,  Chiara Verpelli, 
  • First Published: 08 July 2012
Research Article
Open Access

Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. coli and Y. pseudotuberculosis

Martin May,  Tanja Kolbe,  Tianbang Wang,  Gudula Schmidt,  Harald Genth, 
  • First Published: 05 July 2012
Review Article
Open Access

Pivotal Role of AKAP12 in the Regulation of Cellular Adhesion Dynamics: Control of Cytoskeletal Architecture, Cell Migration, and Mitogenic Signaling

Shin Akakura,  Irwin H. Gelman, 
  • First Published: 28 June 2012
Review Article
Open Access

The Role of p38 MAPK and Its Substrates in Neuronal Plasticity and Neurodegenerative Disease

Sônia A. L. Corrêa,  Katherine L. Eales, 
  • First Published: 25 June 2012
Review Article
Open Access

Beyond Genetics in Glioma Pathways: The Ever-Increasing Crosstalk between Epigenomic and Genomic Events

Ramón Martínez, 
  • First Published: 18 June 2012
Review Article
Open Access

The Small GTPase Rap1b: A Bidirectional Regulator of Platelet Adhesion Receptors

Gianni Francesco Guidetti,  Mauro Torti, 
  • First Published: 14 June 2012
Research Article
Open Access

Effects of Somatic Mutations in the C-Terminus of Insulin-Like Growth Factor 1 Receptor on Activity and Signaling

Barbara P. Craddock,  W. Todd Miller, 
  • First Published: 14 June 2012
Review Article
Open Access

Nucleic Acids in Human Glioma Treatment: Innovative Approaches and Recent Results

S. Catuogno,  C. L. Esposito,  C. Quintavalle,  G. Condorelli,  V. de Franciscis,  L. Cerchia, 
  • First Published: 21 May 2012
Review Article
Open Access

Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma

Luigi Catacuzzeno,  Bernard Fioretti,  Fabio Franciolini, 
  • First Published: 17 May 2012
Review Article
Open Access

Functional Mechanisms and Roles of Adaptor Proteins in Abl-Regulated Cytoskeletal Actin Dynamics

Mizuho Sato,  Masahiro Maruoka,  Tatsuo Takeya, 
  • First Published: 17 May 2012
Research Article
Open Access

A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway

Mitali Bhattacharjee,  Rajesh Raju,  Aneesha Radhakrishnan,  Vishalakshi Nanjappa,  Babylakshmi Muthusamy,  Kamlendra Singh,  Dheebika Kuppusamy,  Bhavya Teja Lingala,  Archana Pan,  Premendu Prakash Mathur,  H. C. Harsha,  T. S. Keshava Prasad,  Gerald J. Atkins,  Akhilesh Pandey,  Aditi Chatterjee, 
  • First Published: 09 May 2012
Research Article
Open Access

In Vivo Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell Kinase

Roman M. Levytskyy,  Nupura Hirve,  David M. Guimond,  Lie Min,  Amy H. Andreotti,  Constantine D. Tsoukas, 
  • First Published: 09 May 2012
Review Article
Open Access

The Role of Bacteria in the Pathogenesis of Ulcerative Colitis

Maiko Sasaki,  Jan-Michael A. Klapproth, 
  • First Published: 24 April 2012
Review Article
Open Access

The Role of Phosphoinositide 3-Kinase Signaling in Intestinal Inflammation

Catherine M. Cahill,  Jack T. Rogers,  W. Allan Walker, 
  • First Published: 09 April 2012
Review Article
Open Access

Crosstalk between p53 and TGF-β Signalling

Rebecca Elston,  Gareth J. Inman, 
  • First Published: 28 March 2012
Research Article
Open Access

Dopamine D2 Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly

Karin F. K. Ejendal,  Carmen W. Dessauer,  Terence E. Hébert,  Val J. Watts, 
  • First Published: 12 March 2012
Review Article
Open Access

The Role of MAPK in Drug-Induced Kidney Injury

Hilary Cassidy,  Robert Radford,  Jennifer Slyne,  Sein O’Connell,  Craig Slattery,  Michael P. Ryan,  Tara McMorrow, 
  • First Published: 12 March 2012
Editorial
Open Access

Reactive Oxygen Species: Friends and Foes of Signal Transduction

Saverio Francesco Retta,  Paola Chiarugi,  Lorenza Trabalzini,  Paolo Pinton,  Alexey M. Belkin, 
  • First Published: 11 March 2012
Research Article
Open Access

The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries

Heather L. Watt,  Zakaria Rachid,  Bertrand J. Jean-Claude, 
  • First Published: 07 March 2012
Review Article
Open Access

Diverse Roles of JNK and MKK Pathways in the Brain

Tokiwa Yamasaki,  Hiroshi Kawasaki,  Hiroshi Nishina, 
  • First Published: 08 February 2012
Review Article
Open Access

The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition

Ting Gui,  Yujing Sun,  Aiko Shimokado,  Yasuteru Muragaki, 
  • First Published: 29 January 2012
Review Article
Open Access

MAPK Usage in Periodontal Disease Progression

Qiyan Li,  Michael S. Valerio,  Keith L. Kirkwood, 
  • First Published: 23 January 2012
Research Article
Open Access

Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness

Maria Letizia Taddei,  Elisa Giannoni,  Giovanni Raugei,  Salvatore Scacco,  Anna Maria Sardanelli,  Sergio Papa,  Paola Chiarugi, 
  • First Published: 04 January 2012
Review Article
Open Access

Extracellular Signal-Regulated Kinase (ERK) Activation and Mitogen-Activated Protein Kinase Phosphatase 1 Induction by Pulsatile Gonadotropin-Releasing Hormone in Pituitary Gonadotrophs

Haruhiko Kanasaki,  Indri Purwana,  Aki Oride,  Tselmeg Mijiddorj,  Kohji Miyazaki, 
  • First Published: 22 December 2011
Research Article
Open Access

Redox Regulation of Nonmuscle Myosin Heavy Chain during Integrin Engagement

Tania Fiaschi,  Giacomo Cozzi,  Paola Chiarugi, 
  • First Published: 19 December 2011
Review Article
Open Access

Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk?

Luca Goitre,  Barbara Pergolizzi,  Elisa Ferro,  Lorenza Trabalzini,  Saverio Francesco Retta, 
  • First Published: 13 December 2011
Review Article
Open Access

Reactive Oxygen Species in Skeletal Muscle Signaling

Elena Barbieri,  Piero Sestili, 
  • First Published: 05 December 2011
Review Article
Open Access

New Insights into the p38γ and p38δ MAPK Pathways

Ana Risco,  Ana Cuenda, 
  • First Published: 30 November 2011
Review Article
Open Access

The Interplay between ROS and Ras GTPases: Physiological and Pathological Implications

Elisa Ferro,  Luca Goitre,  Saverio Francesco Retta,  Lorenza Trabalzini, 
  • First Published: 30 November 2011
Review Article
Open Access

Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging

Saverio Marchi,  Carlotta Giorgi,  Jan M. Suski,  Chiara Agnoletto,  Angela Bononi,  Massimo Bonora,  Elena De Marchi,  Sonia Missiroli,  Simone Patergnani,  Federica Poletti,  Alessandro Rimessi,  Jerzy Duszynski,  Mariusz R. Wieckowski,  Paolo Pinton, 
  • First Published: 14 November 2011
Review Article
Open Access

MAP Kinases and Prostate Cancer

Gonzalo Rodríguez-Berriguete,  Benito Fraile,  Pilar Martínez-Onsurbe,  Gabriel Olmedilla,  Ricardo Paniagua,  Mar Royuela, 
  • First Published: 20 October 2011
Review Article
Open Access

Neurospora crassa Light Signal Transduction Is Affected by ROS

Tatiana A. Belozerskaya,  Natalia N. Gessler,  Elena P. Isakova,  Yulia I. Deryabina, 
  • First Published: 20 October 2011
Review Article
Open Access

Nuclear Transport: A Switch for the Oxidative Stress—Signaling Circuit?

Mohamed Kodiha,  Ursula Stochaj, 
  • First Published: 15 October 2011
Review Article
Open Access

Oxidative Stress Induced by MnSOD-p53 Interaction: Pro- or Anti-Tumorigenic?

Delira Robbins,  Yunfeng Zhao, 
  • First Published: 05 October 2011
Review Article
Open Access

Oxidative Stress, Mitochondrial Dysfunction, and Aging

Hang Cui,  Yahui Kong,  Hong Zhang, 
  • First Published: 02 October 2011
Review Article
Open Access

ROS-Mediated Signalling in Bacteria: Zinc-Containing Cys-X-X-Cys Redox Centres and Iron-Based Oxidative Stress

Darío Ortiz de Orué Lucana,  Ina Wedderhoff,  Matthew R. Groves, 
  • First Published: 29 September 2011